Director Shareholding

Cambridge Antibody Tech Group PLC
14 December 2004

                                  SCHEDULE 11

          NOTIFICATION OF INTERESTS OF DIRECTORS AND CONNECTED PERSONS


1)  Name of company
Cambridge Antibody Technology


2)  Name of director
John Aston


3)  Please state whether notification indicates that it is in respect of
    holding of the shareholder named in 2 above or in respect of a
non-beneficial interest or in the case of an individual holder if it is a
holding of that person's spouse or children under the age of 18 or in respect of
a non-beneficial interest
As in 2 above


4)  Name of the registered holder(s) and, if more than one holder, the
    number of shares held by each of them (if notified)
Greenwood Nominees CREST Account


5)  Please state whether notification relates to a person(s) connected
    with the Director named in 2 above and identify the connected person(s)
As in 2 above


6)  Please state the nature of the transaction. For PEP transactions
    please indicate whether general/single co PEP and if discretionary/non
    discretionary
Sale and Purchase of shares following exercise of Options


7)  Number of shares/amount of
    stock acquired
9,000


8)  Percentage of issued class
0.0218%


9)  Number of shares/amount
    of stock disposed
4,912


10) Percentage of issued class
0.0119%


11) Class of security
Ordinary 10 pence shares


12) Price per share
£6.13


13) Date of transaction
13 December 2004


14) Date company informed
13 December 2004


15) Total holding following this notification
43,088


16) Total percentage holding of issued class following this notification
0.104%


If a director has been granted options by the company please complete the
following boxes

17) Date of grant



18) Period during which or date on which exercisable



19) Total amount paid (if any) for grant of the option



20) Description of shares or debentures involved: class, number



21) Exercise price (if fixed at time of grant) or indication that price
    is to be fixed at time of exercise



22) Total number of shares or debentures over which options held
    following this notification



23) Any additional information
The option which was exercised was due to irrevocably lapse on 19 December 2004
if it had not been exercised prior to that date.


24) Name of contact and telephone number for queries
Justin Hoskins, 01223 898589


25) Name and signature of authorised company official responsible for
    making this notification
Diane Mellett, Company Secretary


Date of Notification. 14 December 2004





                                  SCHEDULE 11

          NOTIFICATION OF INTERESTS OF DIRECTORS AND CONNECTED PERSONS


1)  Name of company
Cambridge Antibody Technology


2)  Name of director
David Glover


3)  Please state whether notification indicates that it is in respect of
    holding of the shareholder named in 2 above or in respect of a
non-beneficial interest or in the case of an individual holder if it is a
holding of that person's spouse or children under the age of 18 or in respect of
a non-beneficial interest
As in 2 above


4)  Name of the registered holder(s) and, if more than one holder, the
    number of shares held by each of them (if notified)
Greenwood Nominees CREST Account in joint holding with spouse


5)  Please state whether notification relates to a person(s) connected
    with the Director named in 2 above and identify the connected person(s)
As in 2 above


6)  Please state the nature of the transaction. For PEP transactions
    please indicate whether general/single co PEP and if discretionary/non
    discretionary

 Purchase of shares following exercise of Options


7)  Number of shares/amount of
    stock acquired
15,000


8)  Percentage of issued class
0.0363%


9)  Number of shares/amount
    of stock disposed
Nil


10) Percentage of issued class
Nil


11) Class of security
Ordinary 10 pence shares


12) Price per share
£6.13


13) Date of transaction
13 December 2004


14) Date company informed
13 December 2004


15) Total holding following this notification
28,730


16) Total percentage holding of issued class following this notification
0.0697%


If a director has been granted options by the company please complete the
following boxes

17) Date of grant



18) Period during which or date on which exercisable



19) Total amount paid (if any) for grant of the option



20) Description of shares or debentures involved: class, number



21) Exercise price (if fixed at time of grant) or indication that price
    is to be fixed at time of exercise



22) Total number of shares or debentures over which options held
    following this notification



23) Any additional information
The option which was exercised was due to irrevocably lapse on 19 December 2004
if it had not been exercised prior to that date.


24) Name of contact and telephone number for queries
Justin Hoskins, 01223 898589


25) Name and signature of authorised company official responsible for
    making this notification
Diane Mellett, Company Secretary


Date of Notification. 14 December 2004









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