Directors Shareholding(s)

Cambridge Antibody Tech Group PLC
11 December 2000



Schedule 11 - Notification of interests of Directors and Connected Persons

1   Name of company:
Cambridge Antibody Technology

2   Name of director:
John Aston

3   Please state whether notification indicates that it is in respect of     
holding of the director named in 2 above or holding of that person's spouse or
children under the age of 18 or in respect of a non- beneficial interest:
As in 2

4   Name of registered holder(s) and, if more than one holder, the number of 
shares held by each of them (if notified):
John Aston and Computershare Trustee Limited

5   Please state whether notification relates to a person(s) connected with  
the director named in 2 above and identify the connected person(s):


6   Please state the nature of the transaction. For PEP transactions please  
indicate whether general/single co PEP and if discretionary/non discretionary:
Exercise of 10,000 options and grant of 90 shares in Company Inland Revenue
Approved Employee Share Ownership Plan (AESOP) pursuant to terms of the Plan.

7   Number of shares/amount of stock acquired:
10,090

8   Percentage of issued class:
0.03%

9   Number of shares/amount of stock disposed:
Nil

10  Percentage of issued class:
Nil

11  Class of security:
10p ordinary shares

12  Price per share:
Options £3.00 per share.  AESOP shares £33.02.

13  Date of transaction:
December 8, 2000

14  Date company informed:
December 8, 2000

15  Total holding following this notification:
12,579

16  Total percentage holding of issued class following this notification:
0.04%

If a director has been granted options by the company, please complete the
following fields:

17  Date of grant:


18  Period during which or date on which exercisable:


19  Total amount paid (if any) for grant of the option:


20  Description of shares or debentures involved: class, number:


21  Exercise price (if fixed at time of grant) or indication that price is to
be fixed at time of exercise:


22  Total number of shares or debentures over which options held following
this notification:


23  Contact name for queries:
Diane Mellett

24  Contact telephone number:
01763 263233

25  Name of company official responsible for making notification:
Company Secretary




Schedule 11 - Notification of interests of Directors and Connected Persons

1   Name of company:
Cambridge Antibody Technology

2   Name of director:
David Chiswell

3   Please state whether notification indicates that it is in respect of     
holding of the director named in 2 above or holding of that person's spouse or
children under the age of 18 or in respect of a non- beneficial interest:
As in 2

4   Name of registered holder(s) and, if more than one holder, the number of 
shares held by each of them (if notified):
Computershare Trustee Limited

5   Please state whether notification relates to a person(s) connected with  
the director named in 2 above and identify the connected person(s):


6   Please state the nature of the transaction. For PEP transactions please  
indicate whether general/single co PEP and if discretionary/non discretionary:
Grant of 90 shares in Company Inland Revenue Approved Employee Share Ownership
Plan (AESOP) pursuant to terms of the Plan.

7   Number of shares/amount of stock acquired:
90

8   Percentage of issued class:
0.00%

9   Number of shares/amount of stock disposed:
Nil

10  Percentage of issued class:
Nil

11  Class of security:
10p Ordinary shares

12  Price per share:
£33.02

13  Date of transaction:
December 8, 2000

14  Date company informed:
December 8, 2000

15  Total holding following this notification:
476,217

16  Total percentage holding of issued class following this notification:
1.35%

If a director has been granted options by the company, please complete the
following fields:

17  Date of grant:


18  Period during which or date on which exercisable:


19  Total amount paid (if any) for grant of the option:


20  Description of shares or debentures involved: class, number:


21  Exercise price (if fixed at time of grant) or indication that price is to
be fixed at time of exercise:


22  Total number of shares or debentures over which options held following
this notification:


23  Contact name for queries:
Diane Mellett

24  Contact telephone number:
01763 263233

25  Name of company official responsible for making notification:
Company Secretary




Schedule 11 - Notification of interests of Directors and Connected Persons

1   Name of company:
Cambridge Antibody Technology

2   Name of director:
David Glover

3   Please state whether notification indicates that it is in respect of     
holding of the director named in 2 above or holding of that person's spouse or
children under the age of 18 or in respect of a non- beneficial interest:
As in 2

4   Name of registered holder(s) and, if more than one holder, the number of 
shares held by each of them (if notified):
Computershare Trustees Limited

5   Please state whether notification relates to a person(s) connected with  
the director named in 2 above and identify the connected person(s):


6   Please state the nature of the transaction. For PEP transactions please  
indicate whether general/single co PEP and if discretionary/non discretionary:
Grant of 90 shares in Company Inland Revenue Approved Employee Share Ownership
Plan (AESOP) pursuant to terms of the Plan.

7   Number of shares/amount of stock acquired:
90

8   Percentage of issued class:
0.00%

9   Number of shares/amount of stock disposed:
Nil

10  Percentage of issued class:
Nil

11  Class of security:
10p Ordinary shares

12  Price per share:
£33.02

13  Date of transaction:
December 8, 2000

14  Date company informed:
December 8, 2000

15  Total holding following this notification:
9,417

16  Total percentage holding of issued class following this notification:
0.03%

If a director has been granted options by the company, please complete the
following fields:

17  Date of grant:


18  Period during which or date on which exercisable:


19  Total amount paid (if any) for grant of the option:


20  Description of shares or debentures involved: class, number:


21  Exercise price (if fixed at time of grant) or indication that price is to
be fixed at time of exercise:


22  Total number of shares or debentures over which options held following
this notification:


23  Contact name for queries:
Diane Mellett

24  Contact telephone number:
01763 263233

25  Name of company official responsible for making notification:
Company Secretary




Schedule 11 - Notification of interests of Directors and Connected Persons

1   Name of company:
Cambridge Antibody Technology

2   Name of director:
Kevin Johnson

3   Please state whether notification indicates that it is in respect of     
holding of the director named in 2 above or holding of that person's spouse or
children under the age of 18 or in respect of a non- beneficial interest:
As in 2

4   Name of registered holder(s) and, if more than one holder, the number of 
shares held by each of them (if notified):
Computershare Trustee Limited

5   Please state whether notification relates to a person(s) connected with  
the director named in 2 above and identify the connected person(s):


6   Please state the nature of the transaction. For PEP transactions please  
indicate whether general/single co PEP and if discretionary/non discretionary:
Grant of 90 shares in Company Inland Revenue Approved Employee Share Ownership
Plan (AESOP) pursuant to terms of the Plan.

7   Number of shares/amount of stock acquired:
90

8   Percentage of issued class:
0.00%

9   Number of shares/amount of stock disposed:
Nil

10  Percentage of issued class:
Nil

11  Class of security:
10p Ordinary shares

12  Price per share:
£33.02

13  Date of transaction:
December 8, 2000

14  Date company informed:
December 8, 2000

15  Total holding following this notification:
63,717

16  Total percentage holding of issued class following this notification:
0.18%

If a director has been granted options by the company, please complete the
following fields:

17  Date of grant:


18  Period during which or date on which exercisable:


19  Total amount paid (if any) for grant of the option:


20  Description of shares or debentures involved: class, number:


21  Exercise price (if fixed at time of grant) or indication that price is to
be fixed at time of exercise:


22  Total number of shares or debentures over which options held following
this notification:


23  Contact name for queries:
Diane Mellett

24  Contact telephone number:
01763 263233

25  Name of company official responsible for making notification:
Company Secretary




Schedule 11 - Notification of interests of Directors and Connected Persons

1   Name of company:
Cambridge Antibody Technology

2   Name of director:
John Stocker

3   Please state whether notification indicates that it is in respect of     
holding of the director named in 2 above or holding of that person's spouse or
children under the age of 18 or in respect of a non- beneficial interest:
As in 2

4   Name of registered holder(s) and, if more than one holder, the number of 
shares held by each of them (if notified):
John Stocker

5   Please state whether notification relates to a person(s) connected with  
the director named in 2 above and identify the connected person(s):


6   Please state the nature of the transaction. For PEP transactions please  
indicate whether general/single co PEP and if discretionary/non discretionary:
Exercise of 75,000 options

7   Number of shares/amount of stock acquired:
75,000

8   Percentage of issued class:
0.21%

9   Number of shares/amount of stock disposed:
Nil

10  Percentage of issued class:
Nil

11  Class of security:
10p Ordinary shares

12  Price per share:
£1.28

13  Date of transaction:
December 8, 2000

14  Date company informed:
December 8, 2000

15  Total holding following this notification:
78,292

16  Total percentage holding of issued class following this notification:
0.22%

If a director has been granted options by the company, please complete the
following fields:

17  Date of grant:


18  Period during which or date on which exercisable:


19  Total amount paid (if any) for grant of the option:


20  Description of shares or debentures involved: class, number:


21  Exercise price (if fixed at time of grant) or indication that price is to
be fixed at time of exercise:


22  Total number of shares or debentures over which options held following
this notification:


23  Contact name for queries:
Diane Mellett

24  Contact telephone number:
01763 263233

25  Name of company official responsible for making notification:
Company Secretary


Additional Information: