Holding in Company

Cambridge Antibody Tech Group PLC
27 September 2001


                                 SCHEDULE 10

                  NOTIFICATION OF MAJOR INTERESTS IN SHARES

 1. Name of company

Cambridge Antibody Technology


2) Name of shareholder having a major interest
Fidelity Investments


3) Please state whether notification indicates that it is in respect of
holding of the shareholder named in 2 above or in respect of a
non-beneficial interest or in the case of an individual holder if it is a
holding of that person's spouse or children under the age of 18
As in 2 above


4) Name of the registered holder(s) and, if more than one holder, the
number of shares held by each of them
Chase Nominees Limited (1,151,701) State Street Nominees Limited (246,975)
HSBC (1,534,275) Nortrust Nominees (1,760) State Street Nominees Limited
(32,000) Clydesdale Bank (Head Office) Nominees Limited (5,382) Chase Nominees
Limited (157,000) Bankers Trust (145,800) MSS Nominees Limited (21,200) Bank
of New York Europe (11,000) BT Globenet Nominees Limited (5,100) Bank of New
York Europe (15,700) Nortrust Nominees Limited (93,900) Chase Nominees Limited
(149,700) RBS Trust Bank (111,300) HSBC (24,610) Northern Trust (106,800) BT
Globenet Nominees Limited (22,000) Morgan Stanley (35,039) Bankers Trust
(9,300) Bank of New York Europe (10,500) Citibank (4,400) Clydesdale Bank
(Head Office) Nominees Limited (400) HSBC Client Holdings Nominees (UK)
Limited (33,880) Bank of New York - London (6,500)


5) Number of shares/amount of stock acquired
367,469


6) Percentage of issued class
1.04%


7) Number of shares/amount of stock disposed
Nil


8) Percentage of issued class
Nil


9) Class of security
Ordinary 10p shares


10) Date of transaction
Not disclosed


11) Date company informed
27 September 2001


12) Total holding following this notification
3,936,222



13) Total percentage holding of issued class following this notification
11.10%


14) Any additional information
None


15) Name of contact and telephone number for queries
Diane Mellett 01763 263233


16) Name and signature of authorised company official responsible for
making this notification

Diane Mellett Company Secretary

Date of notification 27 September 2001