Holding in Company

Cambridge Antibody Tech Group PLC
20 November 2001

                                 SCHEDULE 10

                  NOTIFICATION OF MAJOR INTERESTS IN SHARES


1) Name of company
Cambridge Antibody Technology


2) Name of shareholder having a major interest
Fidelity Investments


3) Please state whether notification indicates that it is in respect of
holding of the shareholder named in 2 above or in respect of a
non-beneficial interest or in the case of an individual holder if it is a
holding of that person's spouse or children under the age of 18
Non Beneficial


4) Name of the registered holder(s) and, if more than one holder, the
number of shares held by each of them
Chase Nominees Limited (1,174,446) State Street Nominees Limited (97,830) HSBC
(1,423,234) Nortrust Nominees (950) State Street Nominees Limited (14,800)
Chase Nominees Limited (5,382) Chase Nominees Limited (190,600) Bankers Trust
(182,000) MSS Nominees Limited (26,500) Bank of New York Europe (38,300) BT
Globenet Nominees Limited (7,200) Nortrust Nominees Limited (123,800) Chase
Nominees Limited (151,720) RBS Trust Bank (144,300) HSBC (11,276) Northern
Trust (123,600) BT Globenet Nominees Limited (26,400) Morgan Stanley (49,739)
Bankers Trust (13,300) Bank of New York Europe (14,400) Citibank (6,100) HSBC
Client Holdings Nominees (UK) Limited (33,880) Bank of New York - London
(8,400) JP Morgan (1,410) State Street Nominees Limited (5,250)


5) Number of shares/amount of stock acquired
Nil


6) Percentage of issued class
Nil


7) Number of shares/amount of stock disposed
61,405


8) Percentage of issued class
0.17%


9) Class of security
Ordinary 10p shares


10) Date of transaction
Not disclosed


11) Date company informed
20 November 2001


12) Total holding following this notification
3,874,817



13) Total percentage holding of issued class following this notification
10.93%


14) Any additional information
None


15) Name of contact and telephone number for queries
Diane Mellett 01763 263233


16) Name and signature of authorised company official responsible for
making this notification

Diane Mellett Company Secretary

Date of notification 20 November 2001