Holding in Company

Cambridge Antibody Tech Group PLC
19 December 2001


                                 SCHEDULE 10

                  NOTIFICATION OF MAJOR INTERESTS IN SHARES

1) Name of company

 a. Cambridge Antibody Technology


    2) Name of shareholder having a major interest

    Fidelity Investments



        3) Please state whether notification indicates that it is in respect
        of
        holding of the shareholder named in 2 above or in respect of a
        non-beneficial interest or in the case of an individual holder if it
        is a
        holding of that person's spouse or children under the age of 18

        Non Beneficial

        4) Name of the registered holder(s) and, if more than one holder, the
        number of shares held by each of them

        Chase Nominees Limited (1,040,576), State Street Nominees Limited
        (139,600), HSBC (1,110,275), State Street Nominees Ltd.
        (4,700),Nortrust Nominees Ltd (123,200), Chase Nominees Ltd (151,820),
        RBS Trust Bank (146,400), HSBC (4,310), Northern Trust (155,100), BT
        Globenet Nominees Ltd (27,000), Morgan Stanley (49,739), Bankers Trust
        (13,300), Bank of New York Europe (14,400), Citibank (6,100), HSBC
        Clinet Holdings Nominee (UK) Limited (33,880), Bank of New York -
        London(9,000), JP Morgan (1,510), (unspecified) (9,600),Chase Nomiees
        Ltd (5,382), Chase Nominees Ltd (189,000), Bankers Trust (183,200),
        MSS Nominees Ltd (26,500), Bank of New York Europe (37,700), BT
        Globebet Nominees Ltd (7,000)

        5) Number of shares/amount of stock acquired

        NIL


        6) Percentage of issued class

        NIL


        7) Number of shares/amount of stock disposed

        385,525

        8) Percentage of issued class

        1.084%

        9) Class of security

        Ordinary 10p Shares

        10) Date of transaction

        Not disclosed

        11) Date company informed

        18 December 2001

        12) Total holding following this notification

        3,489,292


        13) Total percentage holding of issued class following this
        notification

        9.823%

        14) Any additional information

        None

        15) Name of contact and telephone number for queries

        Diane Mellett 01763 263233

        16) Name and signature of authorised company official responsible for
        making this notification

        Date of notification 19 December, 2001