Holding(s) in Company

Cambridge Antibody Tech Group PLC
15 January 2003

                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES

1) Name of company

Cambridge Antibody Technology

2) Name of shareholder having a major interest

FMR Corp, Fidelity International Ltd and Mr Edward C. Johnson 3d

3) Please state whether notification indicates that it is in respect of
holding of the shareholder named in 2 above or in respect of a
non-beneficial interest or in the case of an individual holder if it is a
holding of that person's spouse or children under the age of 18

Non beneficial

4) Name of the registered holder(s) and, if more than one holder, the
number of shares held by each of them

Chase Nominees Limited (1,060,242), State Street Nominees Limited (130,570),
HSBC (1,012,375), Chase Manhattan Bank London (5,382), Chase Nominees Ltd
(260,299), Bankers Trust (277,628), MSS Nominees Ltd (31,800), Bank of New York
Europe (24,800), BT Globenet Nominees Ltd (4,600), Nortrust Nominees Ltd
(117,700), RBS Trust Bank (156,237), Northern Trust (86,907), BT Globenet
Nominees Ltd (47,900), Morgan Stanley(37,685), Bankers Trust (9,800), Bank of
New York Europe (9,500), Citibank (4,000), Bank of New York - London (45,700),
JP Morgan (74,961), State Street Nominees Ltd (25,700), Bank of New York
Brussels (58,800), State Street Bank & Trust (12,500).

5) Number of shares/amount of stock acquired

Nil

6) Percentage of issued class

Nil

7) Number of shares/amount of stock disposed

3,495,086

8) Percentage of issued class

1.173%

9) Class of security

Ordinary 10p shares

10) Date of transaction

Not disclosed

11) Date company informed

14 January 2003

12) Total holding following this notification

3,495,086


13) Total percentage holding of issued class following this notification

9.61%

14) Any additional information

None of the entities act as a group or in concert in respect of the interests
notified.

15) Name of contact and telephone number for queries

Justin Hoskins, 01223 471471

16) Name and signature of authorised company official responsible for
making this notification

Diane Mellett, Company Secretary


Date of notification 15 January 2003




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