Holding(s) in Company

Cambridge Antibody Tech Group PLC
08 September 2004


                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


1)   Name of company

Cambridge Antibody Technology Group plc

2)   Name of shareholder having a major interest

Janus Capital Management LLC

3)   Please state whether notification indicates that it is in respect of
     holding of the shareholder named in 2 above or in respect of a
     non-beneficial interest or in the case of an individual holder if it is a
     holding of that person's spouse or children under the age of 18


non-beneficial


4)   Name of the registered holder(s) and, if more than one holder, the
     number of shares held by each of them


Janus Capital Management LLC


5)   Number of shares/amount of stock acquired

Not stated


6)   Percentage of issued class

Not stated

7)   Number of shares/amount of stock disposed

Not stated

8)   Percentage of issued class

N/A

9)   Class of security

Ordinary 10 pence shares

10)  Date of transaction

2 September 2004

11)  Date company informed

8 September 2004

12)  Total holding following this notification

1,625,549 Ordinary 10 pence shares











13)  Total percentage holding of issued class following this notification

3.95%

14)  Any additional information

None


15)  Name of contact and telephone number for queries

Justin Hoskins 01223 898589

16)  Name and signature of authorised company official responsible for
     making this notification


Diane Mellett, Company Secretary



Date of notification: 8 September 2004



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