Holding(s) in Company

Cambridge Antibody Tech Group PLC
21 October 2004

                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


1)   Name of company

Cambridge Antibody Technology

2)   Name of shareholder having a major interest

Goldman Sachs Group, Inc

3)   Please state whether notification indicates that it is in respect of
     holding of the shareholder named in 2 above or in respect of a
     non-beneficial interest or in the case of an individual holder if it is a
     holding of that person's spouse or children under the age of 18

1,089,604 shares - Goldman Sachs Securities (Nominees) Limited - non beneficial
116,200 shares   - The Depositary Trust Company, New York      - non beneficial
100 shares       - Depositary Trust Company                    - as in 2) above
1,400 shares     - GSSN                                        - as in 2) above
334,864 shares   - Goldman Sachs International (CREPTEMP)      - as in 2) above
128,400 shares   - JB Were Managed Funds Limited               - non beneficial


4)   Name of the registered holder(s) and, if more than one holder, the
     number of shares held by each of them

1,089,604 shares - Goldman Sachs Securities (Nominees) Limited
116,200 shares   - The Depositary Trust Company, New York
100 shares       - Depositary Trust Company
1,400 shares     - GSSN
334,864 shares   - Goldman Sachs International (CREPTEMP)
128,400 shares   - JB Were Managed Funds Limited

5)   Number of shares/amount of stock acquired

Not known

6)   Percentage of issued class

N/A

7)   Number of shares/amount of stock disposed

Not known

8)   Percentage of issued class

N/A

9)   Class of security

Ordinary 10 pence shares

10)  Date of transaction

Not known

11)  Date company informed

21 October 2004

12)  Total holding following this notification

1,670,568 ordinary 10 pence shares


13)  Total percentage holding of issued class following this notification

4.06%

14)  Any additional information



15)  Name of contact and telephone number for queries

Justin Hoskins, 01223 898589

16)  Name and signature of authorised company official responsible for
     making this notification


Diane Mellett, Company Secretary


     Date of notification 21 October 2004





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