Holding(s) in Company

Cambridge Antibody Tech Group PLC
17 November 2004

                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


1)   Name of company

Cambridge Antibody Technology

2)   Name of shareholder having a major interest

The Goldman Sachs Group Inc


3)   Please state whether notification indicates that it is in respect of
     holding of the shareholder named in 2 above or in respect of a
     non-beneficial interest or in the case of an individual holder if it is a
     holding of that person's spouse or children under the age of 18

Goldman Sachs Securities (Nominees) Limited           non-beneficial

The Depositary Trust Company, New York                non-beneficial

Goldman Sachs Securities (Nominees) Limited           beneficial

Goldman Sachs International (CREST a/c CREPTEMP)      beneficial

Goldman Sachs JBWere Managed Funds Limited            beneficial


4)   Name of the registered holder(s) and, if more than one holder, the
     number of shares held by each of them

Goldman Sachs Securities (Nominees) Limited           982,354

The Depositary Trust Company, New York               113,200

Goldman Sachs Securities (Nominees) Limited             1,400

Goldman Sachs International (CREST a/c CREPTEMP)      407,355

Goldman Sachs JBWere Managed Funds Limited            128,400


5)   Number of shares/amount of stock acquired

not disclosed


6)   Percentage of issued class

N/A


7)   Number of shares/amount of stock disposed

None


8)   Percentage of issued class

N/A


9)   Class of security

Ordinary 10 pence shares


10)  Date of transaction

Not known


11)  Date company informed

16 November 2004


12)  Total holding following this notification

1,632,709 ordinary 10 pence shares

13)  Total percentage holding of issued class following this notification

3.97%


14)  Any additional information

None


15)  Name of contact and telephone number for queries

Justin Hoskins 01223 898589


16)  Name and signature of authorised company official responsible for
     making this notification


Diane Mellett, Company Secretary


     Date of notification 17 November 2004





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