Holding(s) in Company

Cambridge Antibody Tech Group PLC
29 December 2004



                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


1)   Name of company


Cambridge Antibody Technology

2)   Name of shareholder having a major interest

The Goldman Sachs Group Inc


3)   Please state whether notification indicates that it is in respect of
     holding of the shareholder named in 2 above or in respect of a
     non-beneficial interest or in the case of an individual holder if it is a
     holding of that person's spouse or children under the age of 18

Goldman Sachs Securities (Nominees) Limited                 non-beneficial
The Depositary Trust Company, New York                      non-beneficial
The Depositary Trust Company, New York                      beneficial
Goldman Sachs Securities (Nominees) Limited                 beneficial
Goldman Sachs International (CREST a/c CREPTEMP)            beneficial
Goldman Sachs JBWere Managed Funds Limited                  beneficial

4)   Name of the registered holder(s) and, if more than one holder, the
     number of shares held by each of them

Goldman Sachs Securities (Nominees) Limited                 916,955
The Depositary Trust Company, New York                      243,065
The Depositary Trust Company, New York                          200
Goldman Sachs Securities (Nominees) Limited                   1,400
Goldman Sachs International (CREST a/c CREPTEMP)            473,662
Goldman Sachs JBWere Managed Funds Limited                  128,400


5)   Number of shares/amount of stock acquired 

not disclosed


6)   Percentage of issued class 

not known


7)   Number of shares/amount of stock disposed

None


8)   Percentage of issued class

N/A


9)   Class of security

Ordinary 10 pence shares


10)  Date of transaction

Not known


11)  Date company informed

29 December 2004


12)  Total holding following this notification

1,763,682


13)  Total percentage holding of issued class following this notification

3.427%


14)  Any additional information

None


15)  Name of contact and telephone number for queries

Justin Hoskins 01223 898589


16)  Name and signature of authorised company official responsible for
     making this notification

Diane Mellett, Company Secretary

     Date of notification 29 December 2004





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