Holding(s) in Company

Cambridge Antibody Tech Group PLC
03 March 2006

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES



1. Name of company



Cambridge Antibody Technology Group plc



2. Name of shareholder having a major interest



OrbiMed



3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18



As in 2. above



4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them



Not known



5. Number of shares / amount of stock acquired



N/A



6. Percentage of issued class



N/A



7. Number of shares / amount of stock disposed



Not known



8. Percentage of issued class



Not Known



9. Class of security



Ordinary 10 pence Shares



10. Date of transaction



Not known



11. Date company informed



3 March 2006



12. Total holding following this notification



Not known



13. Total percentage holding of issued class following this notification



Not known



14. Any additional information



The Company has been advised that Orbimed Advisors LLC and OrbiMed Capital LLC
(collectively "Orbimed" ), through various entities over which it has
investment discretion, no longer has any interest in ordinary shares or ADR's of
the Company



15. Name of contact and telephone number for queries



Justin Hoskins, 01223 898589



16. Name and signature of authorised company official responsible for making
this notification



Justin Hoskins, Company Secretary



Date of notification



3 March 2006



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