Holding(s) in Company

Cambridge Antibody Tech Group PLC
18 August 2005

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


1. Name of company

Cambridge Antibody Technology Group plc

2. Name of shareholder having a major interest

The Goldman Sachs Group Inc.

3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18

Goldman Sachs Securities (Nominees) Limited               non beneficial
The Depositary Trust Company, New York                    non beneficial
Goldman Sachs Securities (Nominees) Limited                   beneficial
Goldman Sachs International (CREST a/c CREPTEMP)              beneficial
Goldman Sachs JBWere Managed Funds Limited                    beneficial


4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them

Goldman Sachs Securities (Nominees) Limited                      748,435
The Depositary Trust Company, New York                           473,965
Goldman Sachs Securities (Nominees) Limited                        1,400
Goldman Sachs International (CREST a/c CREPTEMP)                 554,903
Goldman Sachs JBWere Managed Funds Limited                       160,645


5. Number of shares / amount of stock acquired

not disclosed


6. Percentage of issued class

not known


7. Number of shares / amount of stock disposed

None


8. Percentage of issued class

N/A


9. Class of security

Ordinary 10 pence shares


10. Date of transaction

16 August 2005


11. Date company informed

17 August 2005


12. Total holding following this notification

1,939,348


13. Total percentage holding of issued class following this notification

3.756%


14. Any additional information

None


15. Name of contact and telephone number for queries

Justin Hoskins 01223 898589


16. Name and signature of authorised company official responsible for making
this notification

Justin Hoskins, Company Secretary


Date of notification

17 August 2005



The FSA does not give any express or implied warranty as to the accuracy of this
document or material and does not accept any liability for error or omission.
The FSA is not liable for any damages (including, without limitation, damages
for loss of business or loss of profits) arising in contract, tort or otherwise
from the use of or inability to use this document, or any material contained in
it, or from any action or decision taken as a result of using this document or
any such material.




                      This information is provided by RNS
            The company news service from the London Stock Exchange