ODM meta - analysis

Deltex Medical Group PLC 03 March 2008 Deltex Medical Group plc Independent analysis of clinical trial data further confirms clinical benefit of oesophageal Doppler-guided fluid delivery in abdominal surgery. 3 March 2008 - Deltex Medical Group plc ('Deltex Medical'), the UK's leading haemodynamic monitoring company, notes the publication of an article in the International Journal of Clinical Practice that examines the use of oesophageal Doppler monitoring (ODM) to guide fluid delivery in patients undergoing major abdominal surgery. Doctors from the departments of surgery and anaesthesia at the Cambridge University Hospitals NHS Trust examined results from the four previously published randomised controlled clinical trials into the use of ODM in abdominal surgery. The results, involving a total of almost 400 patients, were combined using the stringent statistical technique known as meta-analysis. The authors reported that use of ODM in abdominal surgery, based on the pooled data analysed, resulted in significantly fewer post-operative complications and a consequent significant reduction in length of hospital stay. Deltex Medical's Chief Executive, Andy Hill commented: 'This article further supports the growing belief that the use of Deltex Medical's CardioQ(TM) oesophageal Doppler monitor to guide fluid delivery should be routine clinical practice in abdominal and other major surgery.' The full reference for the article is: Walsh SR, Tang T, Bass S and Gaunt ME. Doppler-guided intra-operative fluid management during major abdominal surgery: systematic review and meta-analysis Int J Clin Pract. March 2008. 62, 3 466-470 For further information, please contact:- Deltex Medical Group plc 01243 774 837 Nigel Keen, Chairman njk@deltexmedical.com Andy Hill, Chief Executive ahill@deltexmedical.com Ewan Phillips, Finance Director eap@deltexmedical.com Gavin Anderson & Company 020 7554 1400 Deborah Walter dwalter@gavinanderson.co.uk Robert Speed rspeed@gavinanderson.co.uk Charles Stanley Securities 020 7149 6000 Nominated Advisor Philip Davies philip.davies@csysecurities.com Russell Cook russell.cook@csysecurities.com Notes for Editors Deltex Medical manufactures and markets the CardioQ(TM) monitor, which uses disposable ultra-sound probes inserted into the oesophagus to determine the amount of blood being pumped around the body - 'circulating blood volume'. Reduced circulating blood volume is known as hypovolaemia, which leads to insufficient oxygen being delivered to the organs. This causes medical complications including peripheral and major organ failure which can lead to death. Hypovolaemia, which is akin to severe dehydration, affects virtually every patient having surgery because of the combined effects of pre-operative starvation, the impact of the anaesthetic agents and trauma from the surgery itself. Using fluids and drugs, guided by the CardioQ, to optimise the amount of circulating blood significantly reduces post-operative complications allowing patients to make a faster, more complete recovery and return home earlier. The CardioQ incorporates the Company's proprietary software and a small diameter, easy-to-use, minimally invasive, disposable oesophageal probe that is used for transmitting and receiving an ultra-sound signal. By using this technology, the CardioQ provides clinicians with the ability to haemodynamically optimise critically ill patients and those undergoing routine moderate to major surgery through the controlled administration of fluid and drugs. Haemodynamic optimisation has been scientifically proven to improve the speed and quality of patient recovery and reduce hospital stay. There are already over 1,250 CardioQs currently in use in hospitals worldwide and distribution arrangements are in place in over 30 countries. In addition, there are currently more than 90 clinical publications on the use of the CardioQ which have repeatedly:- • Validated the results of the Monitor against known standards for measuring cardiac output, demonstrating that the technology works • Proved that the CardioQ works in a wide range of surgical procedures • Demonstrated that the Company's technology provides significant health and economic benefits by helping to reduce post-operative complications and length of hospital stays by an average of 30 to 40 per cent for a wide range of patients. The SupraQ(TM) is an entirely non-invasive device which uses an ultrasound probe held at the base of the patient's neck to track the flow of blood in the aorta; it presents the same data as the CardioQ in a similar format and is used for taking snapshots or monitoring over short periods. This information is provided by RNS The company news service from the London Stock Exchange
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