Positive Meta-analysis Result

Deltex Medical Group PLC 26 September 2006 Deltex Medical Group plc Presentation of independent systematic review and meta-analysis of clinical data supporting the use of CardioQTM to reduce length of hospital stay 26 September 2006 Deltex Medical Group plc ('Deltex Medical' or the 'Company'), the UK's leading haemodynamic monitoring company, today highlights the presentation of the first systematic review and meta-analysis of the published clinical data involving use of peri-operative oesophageal Doppler-guided fluid delivery, a technique which enables doctors to identify and deal with reductions in circulating blood volume that arise as a consequence of surgery and are associated with potentially serious complications. Dr Mark Hamilton, on behalf of co-authors from the Centre for Anaesthesia, University College London and St George's Hospital, London, today presented the results of their review at the European Society of Intensive Care Medicine (ESICM) meeting in Barcelona. The review's primary conclusion was that giving fluid, guided by oesophageal Doppler, significantly reduced hospital length of stay for surgical patients compared to traditional fluid management. Healthcare providers around the world employ meta-analyses to support decisions about funding and reimbursement of new medical technologies. Examples of organisations that undertake such analyses are the National Institute for Health and Clinical Excellence (NICE) in the UK and the Agency for Health Research and Quality (AHRQ) in the USA. Dr Hamilton commented: 'The use of targeted oesophageal Doppler monitoring in the peri-operative period significantly reduces hospital length of stay for surgical patients. There are obvious economic and healthcare benefits to greater use of this simple technology.' Deltex Medical's chief executive, Andy Hill, commented: 'This is the first systematic review of the impact of oesophageal Doppler-guided therapy based on the overwhelming body of clinical data published to date. The positive conclusions reported by Dr Hamilton will only be further strengthened by the addition of the recently published trial from the Freeman hospital in Newcastle that was unavailable for inclusion at the time the review was submitted for presentation by Dr Hamilton. 'The CardioQ oesophageal Doppler haemodynamic monitor has been proven in multiple randomised clinical trials to improve outcomes and reduce length of stay following surgery. I believe that this meta-analysis clearly demonstrates the urgent need to implement the CardioQ as a standard of care for patients undergoing major surgery.' For further information, please contact:- Deltex Medical Group plc 01243 774 837 Nigel Keen, Chairman Andy Hill, Chief Executive Ewan Phillips, Finance Director Gavin Anderson & Company 020 7554 1400 Deborah Walter Marie Cairney Jodie Reilly Charles Stanley Securities 020 7149 6457 Philip Davies Notes for Editors Deltex Medical manufactures and markets the CardioQ monitor, which uses disposable ultra-sound probes inserted into the oesophagus to determine the amount of blood being pumped around the body - 'circulating blood volume'. Reduced circulating blood volume is known as hypovolaemia, which leads to insufficient oxygen being delivered to the organs. This causes medical complications including peripheral and major organ failure which can lead to death. Hypovolaemia, which is akin to severe dehydration, affects virtually every patient having surgery because of the combined effects of pre-operative starvation, the impact of the anaesthetic agents and trauma from the surgery itself. Using fluids and drugs, guided by the CardioQ, to optimise the amount of circulating blood significantly reduces post-operative complications allowing patients to make a faster, more complete recovery and return home earlier. The CardioQ incorporates the Company's proprietary software and a small diameter, easy-to-use, minimally invasive, disposable oesophageal probe that is used for transmitting and receiving an ultra-sound signal. By using this technology, the CardioQ provides clinicians with the ability to haemodynamically optimise critically ill patients and those undergoing routine moderate to major surgery through the controlled administration of fluid and drugs. Haemodynamic optimisation has been scientifically proven to improve the speed and quality of patient recovery and reduce hospital stay. There are already over 1,250 CardioQs currently in use in hospitals worldwide and distribution arrangements are in place in over 30 countries. In addition, there are currently more than 90 clinical publications on the use of the CardioQ which have repeatedly:- • Validated the results of the Monitor against known standards for measuring cardiac output, demonstrating that the technology works • Proved that the CardioQ works in a wide range of surgical procedures • Demonstrated that the Company's technology provides significant health and economic benefits by helping to reduce post-operative complications and length of hospital stays by an average of 30 to 40 per cent for a wide range of patients. This information is provided by RNS The company news service from the London Stock Exchange
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