Research Update

Deltex Medical Group PLC 1 September 2004 Deltex Medical Group plc Publication of study results on the use of CardioQ TM haemodynamic monitoring system in patients undergoing colorectal surgery UK, 1 September 2004: Deltex Medical Group plc ('Deltex Medical' or the 'Company'), the AIM listed haemodynamic monitoring company, today announces the publication, in the European Journal of Anaesthesiology, of the results of a National Health Service sponsored pilot study looking at the use of its CardioQ TM system in patients undergoing colorectal (bowel) surgery. Anaesthetist Dr. Howard Wakeling and his surgical colleagues at Worthing Hospital in West Sussex used the CardioQ TM to guide fluid administration during surgery in order to alleviate the dehydration ('hypovolaemia') that affects almost all patients undergoing moderate and major surgical procedures. Hypovolaemia commonly causes post-surgical complications that can extend hospital stay and slow recovery. In severe cases hypovolaemia can lead to death. Dr. Wakeling and his colleagues reported that patients who were haemodynamically optimised using the CardioQ TM system were able to go home on average two days earlier than those managed traditionally and had fewer complications following their surgery. Based upon these findings the investigators embarked upon a prospective, randomised trial of this approach to patient management. The results of this randomised trial will be presented at the Annual Congress of the Association of Anaesthetists of Great Britain and Ireland on 23 September 2004. Chief Executive, Andy Hill, commented: 'These results further support findings already widely reported in the clinical literature and add to the rapidly growing belief within the medical community that haemodynamic optimisation should be a standard of care for all patients undergoing moderate and major surgical procedures. Haemodynamic optimisation brings important benefits to both patients and healthcare systems by reducing the length of time in hospital and the complications associated with hypovolaemia. Using our technology offers a significant opportunity to improve quality of care and realise significant economic benefits.' For further information, please contact:- Deltex Medical Group plc 01243 774 837 Nigel Keen, Chairman nigel.keen@deltexmedical.com Andy Hill, Chief Executive andy.hill@deltexmedical.com Ewan Phillips, Finance Director ewan.phillips@deltexmedical.com Financial Dynamics David Yates david.Yates@fd.com 0207 831 3113 Lucy Briggs lucy.briggs@fd.com Notes for Editors Deltex Medical manufactures and markets the CardioQ monitor, which uses disposable ultra-sound probes inserted into the oesophagus to determine the amount of blood being pumped around the body - 'circulating blood volume'. Reduced circulating blood volume is known as hypovolemia, which leads to insufficient oxygen being delivered to the organs. This causes medical complications including peripheral and major organ failure which can lead to death. Hypovolemia, which is akin to severe dehydration, affects virtually every patient having surgery because of the combined effects of pre-operative starvation, the impact of the anaesthetic agents and trauma from the surgery itself. Using fluids and drugs, guided by the CardioQ, to optimise the amount of circulating blood significantly reduces post-operative complications allowing patients to make a faster, more complete recovery and return home earlier. The CardioQ incorporates the Company's proprietary software and a small diameter, easy-to-use, minimally invasive, disposable oesophageal probe that is used for transmitting and receiving an ultra-sound signal. By using this technology, the CardioQ provides clinicians with the ability to haemodynamically optimise critically ill patients and those undergoing routine moderate to major surgery through the controlled administration of fluid and drugs. Haemodynamic optimisation has been scientifically proven to improve the speed and quality of patient recovery and reduce hospital stay. There are already over 1,250 CardioQs currently in use in hospitals worldwide and distribution arrangements are in place in over 30 countries. In addition, there are currently more than 90 clinical publications on the use of the CardioQ which have repeatedly:- • validated the results of the Monitor against known standards for measuring cardiac output, demonstrating that the technology works • proved that the CardioQ works in a wide range of surgical procedures • demonstrated that the Company's technology provides significant health and economic benefits by helping to reduce post-operative complications and length of hospital stays by an average of 30 to 40 per cent for a wide range of patients. This information is provided by RNS The company news service from the London Stock Exchange
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