Investee Companies

Billam PLC 20 December 2004 Billam Plc Flotation of two investee companies, Physiomics plc and Intellego Holdings plc The directors of Billam Plc (Billam or the Company) are pleased to announce that shares in two investee companies have been admitted to trading on the Alternative Investment Market (AIM) today. Physiomics plc ('Physiomics') The business of Physiomics is the development and sale of services aimed at reducing the high cost of drug development for pharmaceutical and biotechnology companies, principally by optimising the design of their clinical trials through the application of computer-based simulation tools. The services have a particular focus on cancer therapies. Physiomics is also applying its technologies to develop proprietary cancer therapy products for outlicensing and to this end has secured an option to license up to two innovative molecules from a drug development company. Services Physiomics' services apply complex computer-based simulation tools to resolve the two main problems associated with drug development, namely (i) the lack of a biological response to a given dose and (ii) the difficulties involved in determining the adequate dose of a drug. These services combine Physiomics' own patented pharmacodynamic (''PD'') technology (which enables the correct drug dose at the disease site to be predicted at an early stage) with the Bayer Technology Services GmbH's pharmacokinetic (''PK'') technology (which is used to evaluate how much drug reaches the disease site). They represent an innovative collaboration which is designed to satisfy the growing demand for such systems biology products and services to streamline drug development from the preclinical phase through to Phase III. The Directors of Physiomics believe that drug companies will use Physiomics' services to achieve a number of different objectives, for example: •designing the clinical trial, to maximise the chances of a successful outcome; or . •troubleshooting problem trials, in order to identify the remedial action required and salvage drug development programmes; or •evaluating the benefits of buying in, or outlicensing, potential drug development projects. Physiomics shares were admitted to trading on AIM today, Billam has invested c. £500,000 in Physiomics and is interested directly and indirectly in c. 32.5% of the equity. Intellego Holdings plc ('Intellego') Intellego is a work force training and support services business and supplier of e-Learning computer software. Intellego's solutions are based principally on a suite of award-winning software technologies, which are available exclusively in the UK and Ireland from Intellego. Intellego aims to provide its solutions predominately to large commercial and governmental organisations and the company aims to deliver solutions that enable such organisations to develop in-house, their own e-Learning courses and other training materials such as competency tests. Intellego's shares were admitted to trading on AIM on 17 December. Billam has invested £60,000 for 4% of Intellego. Billam's strategy is to invest in businesses that have developed and are commercialising world-leading technologies with applications in fast growing business-to-business markets. For further information Billam Plc 020 7336 1300 Angus Forrest Bishopsgate Communications 020 7430 1600 Maxine Barnes / Dominic Barretto This information is provided by RNS The company news service from the London Stock Exchange

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