Annual Information Update

GlaxoSmithKline PLC
30 March 2007





  ANNUAL INFORMATION UPDATE FOR GLAXOSMITHKLINE PLC FOR THE 12 MONTHS UP TO 30
                                   MARCH 2007




In accordance with the requirements of Prospectus Rules PR 5.2.1R please find below an Annual Information Update for 
GlaxoSmithKline plc ("The Company"). The information referred to in this Update was up to date at the time the 
information was published, but some information may now be out of date.

To avoid an unnecessarily lengthy document the following are summaries of the information and documents published, or 
made available to the public, by the Company throughout the twelve months ended 30 March 2007.

1.                         Announcements made via RNS, a Regulatory Information Service.

The announcements listed below were published on the London Stock Exchange via RNS, a Regulatory Information Service and
can be obtained from their website www.londonstockexchange.com  or the Company's website www.gsk.com

Date                                           Headline

30/03/2007                           Buy Back Programme
30/03/2007                           Transaction in Own Shares
30/03/2007                           Director/PDMR Shareholding
30/03/2007                           Director/PDMR Shareholding
30/03/2007                           Cervarix US Filing
29/03/2007                           Transaction in Own Shares
28/03/2007                           Director/PDMR Shareholding
28/03/2007                           Transaction in Own Shares
28/03/2007                           Director/PDMR Shareholding
28/03/2007                           Director/PDMR Shareholding
27/03/2007                           Transaction in Own Shares
27/03/2007                           Director/PDMR Shareholding
27/03/2007                           Director/PDMR Shareholding
27/03/2007                           Director/PDMR Shareholding
26/03/2007                           Transaction in Own Shares
26/03/2007                           Director/PDMR Shareholding
26/03/2007                           Director/PDMR Shareholding
23/03/2007                           Transaction in Own Shares
23/03/2007                           Director/PDMR Shareholding
22/03/2007                           Transaction in Own Shares
22/03/2007                           Annual Report and Accounts
21/03/2007                           Director/PDMR Shareholding
21/03/2007                           Transaction in Own Shares
20/03/2007                           Director/PDMR Shareholding
20/03/2007                           Transaction in Own Shares
19/03/2007                           Transaction in Own Shares
19/03/2007                           Director/PDMR Shareholding
16/03/2007                           Director/PDMR Shareholding
16/03/2007                           Transaction in Own Shares
15/03/2007                           Transaction in Own Shares
14/03/2007                           Transaction in Own Shares
14/03/2007                           Director/PDMR Shareholding
14/03/2007                           FDA approval of Tykerb
13/03/2007                           Director/PDMR Shareholding
13/03/2007                           Transaction in Own Shares
13/03/2007                           Director/PDMR Shareholding
13/03/2007                           Director/PDMR Shareholding
13/03/2007                           Director/PDMR Shareholding
13/03/2007                           Total Voting Rights
12/03/2007                           Director/PDMR Shareholding
12/03/2007                           Director/PDMR Shareholding
09/03/2007                           Publication ofRegistrationDoc
09/03/2007                           Publication of Offering Circ.
09/03/2007                           Transaction in Own Shares
09/03/2007                           Director/PDMR Shareholding
09/03/2007                           Director/PDMR Shareholding
08/03/2007                           Transaction in Own Shares
07/03/2007                           Director/PDMR Shareholding
06/03/2007                           Director/PDMR Shareholding
06/03/2007                           Transaction in Own Shares
06/03/2007                           Transaction in Own Shares
06/03/2007                           Transaction in Own Shares
06/03/2007                           Director/PDMR Shareholding
05/03/2007                           Director/PDMR Shareholding
05/03/2007                           Transaction in Own Shares
05/03/2007                           Director Declaration
05/03/2007                           Director/PDMR Shareholding
05/03/2007                           Director/PDMR Shareholding
05/03/2007                           Director/PDMR Shareholding
02/03/2007                           Transaction in Own Shares
02/03/2007                           Annual Report and Accounts
02/03/2007                           Annual Report and Accounts
02/03/2007                           Director/PDMR Shareholding
02/03/2007                           Transaction in Own Shares
01/03/2007                           Transaction in Own Shares
01/03/2007                           Director/PDMR Shareholding
28/02/2007                           Director/PDMR Shareholding
28/02/2007                           Transaction in Own Shares
27/02/2007                           Director/PDMR Shareholding
27/02/2007                           Director/PDMR Shareholding
27/02/2007                           Transaction in Own Shares
26/02/2007                           Director/PDMR Shareholding
26/02/2007                           Director/PDMR Shareholding
26/02/2007                           Director/PDMR Shareholding
26/02/2007                           Transaction in Own Shares
23/02/2007                           Director/PDMR Shareholding
23/02/2007                           Director/PDMR Shareholding
23/02/2007                           Holding(s) in Company
22/02/2007                           Transaction in Own Shares
21/02/2007                           Director/PDMR Shareholding
21/02/2007                           Director/PDMR Shareholding
21/02/2007                           Director/PDMR Shareholding
21/02/2007                           Transaction in Own Shares
20/02/2007                           Director/PDMR Shareholding
20/02/2007                           Director/PDMR Shareholding
20/02/2007                           Director/PDMR Shareholding
20/02/2007                           Transaction in Own Shares
19/02/2007                           Transaction in Own Shares
16/02/2007                           Director/PDMR Shareholding
16/02/2007                           Director/PDMR Shareholding
16/02/2007                           Director/PDMR Shareholding
16/02/2007                           Director/PDMR Shareholding
16/02/2007                           Transaction in Own Shares
16/02/2007                           Quest variable sale forward
15/02/2007                           Transaction in Own Shares
14/02/2007                           Director/PDMR Shareholding
14/02/2007                           Transaction in Own Shares
13/02/2007                           Director/PDMR Shareholding
13/02/2007                           Director/PDMR Shareholding
13/02/2007                           Director/PDMR Shareholding
13/02/2007                           Director/PDMR Shareholding
13/02/2007                           Director/PDMR Shareholding
13/02/2007                           Director/PDMR Shareholding
13/02/2007                           Transaction in Own Shares
12/02/2007                           Director/PDMR Shareholding
12/02/2007                           Directorate Change
09/02/2007                           Director/PDMR Shareholding
09/02/2007                           Director/PDMR Shareholding
09/02/2007                           Director/PDMR Shareholding
08/02/2007                           Transaction in Own Shares
08/02/2007                           Final Results
07/02/2007                           Transaction in Own Shares
06/02/2007                           Director/PDMR Shareholding
06/02/2007                           Transaction in Own Shares
06/02/2007                           Director/PDMR Shareholding
06/02/2007                           Director/PDMR Shareholding
05/02/2007                           Transaction in Own Shares
02/02/2007                           Director/PDMR Shareholding
02/02/2007                           Director/PDMR Shareholding
02/02/2007                           Transaction in Own Shares
01/02/2007                           Total Voting Rights
31/01/2007                           Director/PDMR Shareholding
31/01/2007                           Director/PDMR Shareholding
31/01/2007                           Transaction in Own Shares
30/01/2007                           Transaction in Own Shares
29/01/2007                           Director/PDMR Shareholding
29/01/2007                           Director/PDMR Shareholding
29/01/2007                           Director/PDMR Shareholding
29/01/2007                           Transaction in Own Shares
26/01/2007                           Director/PDMR Shareholding
26/01/2007                           Director/PDMR Shareholding
26/01/2007                           Transaction in Own Shares
25/01/2007                           Director/PDMR Shareholding
25/01/2007                           Transaction in Own Shares
24/01/2007                           Director/PDMR Shareholding
23/01/2007                           Director/PDMR Shareholding
23/01/2007                           Transaction in Own Shares
22/01/2007                           Transaction in Own Shares
22/01/2007                           Director/PDMR Shareholding
22/01/2007                           Director/PDMR Shareholding
19/01/2007                           Director/PDMR Shareholding
19/01/2007                           Transaction in Own Shares
18/01/2007                           Transaction in Own Shares
17/01/2007                           Transaction in Own Shares
17/01/2007                           Director/PDMR Shareholding
17/01/2007                           Director/PDMR Shareholding
17/01/2007                           Director/PDMR Shareholding
17/01/2007                           Director/PDMR Shareholding
17/01/2007                           Director/PDMR Shareholding
16/01/2007                           Transaction in Own Shares
16/01/2007                           Director/PDMR Shareholding
16/01/2007                           Director/PDMR Shareholding
16/01/2007                           Director/PDMR Shareholding
16/01/2007                           Director/PDMR Shareholding
16/01/2007                           Director/PDMR Shareholding
12/01/2007                           Director/PDMR Shareholding
12/01/2007                           Director/PDMR Shareholding
12/01/2007                           Director/PDMR Shareholding
12/01/2007                           Transaction in Own Shares
11/01/2007                           Director/PDMR Shareholding
11/01/2007                           Director/PDMR Shareholding
11/01/2007                           Director/PDMR Shareholding
11/01/2007                           Transaction in Own Shares
10/01/2007                           Director/PDMR Shareholding
10/01/2007                           Director/PDMR Shareholding
10/01/2007                           Transaction in Own Shares
09/01/2007                           Director/PDMR Shareholding
09/01/2007                           Director/PDMR Shareholding
08/01/2007                           Transaction in Own Shares
08/01/2007                           Director/PDMR Shareholding
05/01/2007                           Director/PDMR Shareholding
05/01/2007                           Director/PDMR Shareholding
05/01/2007                           Director/PDMR Shareholding
05/01/2007                           Director/PDMR Shareholding
05/01/2007                           Director/PDMR Shareholding
05/01/2007                           Transaction in Own Shares
04/01/2007                           Transaction in Own Shares
03/01/2007                           Director/PDMR Shareholding
03/01/2007                           Director/PDMR Shareholding
03/01/2007                           Director/PDMR Shareholding
03/01/2007                           Transaction in Own Shares
02/01/2007                           Director/PDMR Shareholding
02/01/2007                           Director/PDMR Shareholding
02/01/2007                           Director/PDMR Shareholding
29/12/2006                           Buy Back Programme
22/12/2006                           Director/PDMR Shareholding
22/12/2006                           Director/PDMR Shareholding
22/12/2006                           Director/PDMR Shareholding
22/12/2006                           Director/PDMR Shareholding
21/12/2006                           GSK to acquire Praecis
20/12/2006                           Director/PDMR Shareholding
20/12/2006                           Transaction in Own Shares
20/12/2006                           Director/PDMR Shareholding
19/12/2006                           Transaction in Own Shares
19/12/2006                           Director/PDMR Shareholding
19/12/2006                           Director/PDMR Shareholding
19/12/2006                           Director/PDMR Shareholding
18/12/2006                           Transaction in Own Shares
15/12/2006                           Total Voting Rights
15/12/2006                           Transaction in Own Shares
15/12/2006                           Transaction in Own Shares
14/12/2006                           Director/PDMR Shareholding
13/12/2006                           Director/PDMR Shareholding
13/12/2006                           Director/PDMR Shareholding
13/12/2006                           Transaction in Own Shares
12/12/2006                           Transaction in Own Shares
12/12/2006                           Director/PDMR Shareholding
12/12/2006                           Director/PDMR Shareholding
11/12/2006                           Transaction in Own Shares
08/12/2006                           Acquisition of Domantis
08/12/2006                           Directorate Change
08/12/2006                           Directorate Change
08/12/2006                           Acquisition of Domantis
08/12/2006                           Directorate Change
08/12/2006                           Directorate Change
08/12/2006                           Directorate Change
08/12/2006                           Director/PDMR Shareholding
08/12/2006                           Transaction in Own Shares
06/12/2006                           Director/PDMR Shareholding
06/12/2006                           Transaction in Own Shares
05/12/2006                           Transaction in Own Shares
05/12/2006                           Director/PDMR Shareholding
05/12/2006                           Director/PDMR Shareholding
04/12/2006                           Director/PDMR Shareholding
04/12/2006                           Director/PDMR Shareholding
04/12/2006                           Director/PDMR Shareholding
04/12/2006                           Director/PDMR Shareholding
04/12/2006                           Avandia Positive ADOPT Result
01/12/2006                           Director/PDMR Shareholding
30/11/2006                           Director/PDMR Shareholding
29/11/2006                           Transaction in Own Shares
28/11/2006                           Transaction in Own Shares
28/11/2006                           Director/PDMR Shareholding
28/11/2006                           Director/PDMR Shareholding
28/11/2006                           Director/PDMR Shareholding
27/11/2006                           Transaction in Own Shares
27/11/2006                           Director/PDMR Shareholding
24/11/2006                           Director/PDMR Shareholding
23/11/2006                           Transaction in Own Shares
23/11/2006                           Director/PDMR Shareholding
23/11/2006                           Director/PDMR Shareholding
22/11/2006                           Director/PDMR Shareholding
22/11/2006                           Transaction in Own Shares
22/11/2006                           Director/PDMR Shareholding
22/11/2006                           Director/PDMR Shareholding
20/11/2006                           Director/PDMR Shareholding
20/11/2006                           Director/PDMR Shareholding
20/11/2006                           Director/PDMR Shareholding
20/11/2006                           Transaction in Own Shares
20/11/2006                           Transaction in Own Shares
17/11/2006                           Transaction in Own Shares
16/11/2006                           Transaction in Own Shares
16/11/2006                           Director/PDMR Shareholding
15/11/2006                           Director/PDMR Shareholding
15/11/2006                           Director/PDMR Shareholding
15/11/2006                           Director/PDMR Shareholding
14/11/2006                           Transaction in Own Shares
14/11/2006                           Director/PDMR Shareholding
14/11/2006                           Director/PDMR Shareholding
14/11/2006                           Director/PDMR Shareholding
13/11/2006                           Transaction in Own Shares
10/11/2006                           Director/PDMR Shareholding
10/11/2006                           Director/PDMR Shareholding
10/11/2006                           Transaction in Own Shares
09/11/2006                           Director/PDMR Shareholding
09/11/2006                           Transaction in Own Shares
09/11/2006                           Director/PDMR Shareholding
09/11/2006                           Director/PDMR Shareholding
08/11/2006                           Transaction in Own Shares
08/11/2006                           Director/PDMR Shareholding
08/11/2006                           Director/PDMR Shareholding
08/11/2006                           Director/PDMR Shareholding
07/11/2006                           Director/PDMR Shareholding
07/11/2006                           Director/PDMR Shareholding
06/11/2006                           Transaction in Own Shares
06/11/2006                           Director/PDMR Shareholding
03/11/2006                           Transaction in Own Shares
03/11/2006                           Director/PDMR Shareholding
02/11/2006                           Transaction in Own Shares
01/11/2006                           Transaction in Own Shares
01/11/2006                           Director/PDMR Shareholding
01/11/2006                           Director/PDMR Shareholding
31/10/2006                           Director/PDMR Shareholding
31/10/2006                           Transaction in Own Shares
30/10/2006                           Director/PDMR Shareholding
30/10/2006                           Director/PDMR Shareholding
30/10/2006                           Transaction in Own Shares
27/10/2006                           Transaction in Own Shares
27/10/2006                           Director/PDMR Shareholding
26/10/2006                           Director/PDMR Shareholding
26/10/2006                           Transaction in Own Shares
26/10/2006                           3rd Quarter Results
25/10/2006                           Transaction in Own Shares
24/10/2006                           Director/PDMR Shareholding
24/10/2006                           Director/PDMR Shareholding
24/10/2006                           Transaction in Own Shares
23/10/2006                           Director/PDMR Shareholding
23/10/2006                           Director/PDMR Shareholding
23/10/2006                           Director/PDMR Shareholding
23/10/2006                           Director/PDMR Shareholding
23/10/2006                           Transaction in Own Shares
23/10/2006                           Director/PDMR Shareholding
23/10/2006                           Director/PDMR Shareholding
20/10/2006                           Director/PDMR Shareholding
20/10/2006                           Transaction in Own Shares
19/10/2006                           Transaction in Own Shares
19/10/2006                           Director/PDMR Shareholding
18/10/2006                           Director/PDMR Shareholding
18/10/2006                           Director/PDMR Shareholding
18/10/2006                           Transaction in Own Shares
17/10/2006                           Transaction in Own Shares
17/10/2006                           Director/PDMR Shareholding
16/10/2006                           Director/PDMR Shareholding
16/10/2006                           Director/PDMR Shareholding
16/10/2006                           Director/PDMR Shareholding
16/10/2006                           Transaction in Own Shares
13/10/2006                           Transaction in Own Shares
13/10/2006                           Director/PDMR Shareholding
12/10/2006                           Director/PDMR Shareholding
12/10/2006                           Transaction in Own Shares
11/10/2006                           Transaction in Own Shares
11/10/2006                           Director/PDMR Shareholding
11/10/2006                           Director/PDMR Shareholding
11/10/2006                           Director/PDMR Shareholding
10/10/2006                           Director/PDMR Shareholding
10/10/2006                           Director/PDMR Shareholding
10/10/2006                           Director/PDMR Shareholding
10/10/2006                           Director/PDMR Shareholding
10/10/2006                           Director/PDMR Shareholding
10/10/2006                           Transaction in Own Shares
10/10/2006                           Director/PDMR Shareholding
09/10/2006                           Director/PDMR Shareholding
09/10/2006                           Director/PDMR Shareholding
09/10/2006                           GSK to acquire CNS Inc
06/10/2006                           Transaction in Own Shares
06/10/2006                           Director/PDMR Shareholding
05/10/2006                           Director/PDMR Shareholding
04/10/2006                           Transaction in Own Shares
04/10/2006                           Director/PDMR Shareholding
03/10/2006                           Director/PDMR Shareholding
03/10/2006                           Director/PDMR Shareholding
02/10/2006                           Transaction in Own Shares
02/10/2006                           Director/PDMR Shareholding
02/10/2006                           Director/PDMR Shareholding
02/10/2006                           Director/PDMR Shareholding
29/09/2006                           Buy Back Programme
29/09/2006                           Transaction in Own Shares
28/09/2006                           Director/PDMR Shareholding
28/09/2006                           Transaction in Own Shares
28/09/2006                           Transaction in Own Shares
27/09/2006                           Director/PDMR Shareholding
26/09/2006                           Director/PDMR Shareholding
26/09/2006                           Transaction in Own Shares
25/09/2006                           Director/PDMR Shareholding
25/09/2006                           Director/PDMR Shareholding
22/09/2006                           Director/PDMR Shareholding
22/09/2006                           Director/PDMR Shareholding
22/09/2006                           Director/PDMR Shareholding
22/09/2006                           Transaction in Own Shares
21/09/2006                           Transaction in Own Shares
21/09/2006                           Director/PDMR Shareholding
20/09/2006                           Director/PDMR Shareholding
20/09/2006                           Transaction in Own Shares
19/09/2006                           Director/PDMR Shareholding
19/09/2006                           Transaction in Own Shares
18/09/2006                           Transaction in Own Shares
18/09/2006                           Director/PDMR Shareholding
15/09/2006                           Transaction in Own Shares
14/09/2006                           Director/PDMR Shareholding
14/09/2006                           Director/PDMR Shareholding
14/09/2006                           Director/PDMR Shareholding
13/09/2006                           Director/PDMR Shareholding
13/09/2006                           Director/PDMR Shareholding
13/09/2006                           Director/PDMR Shareholding
13/09/2006                           Transaction in Own Shares
12/09/2006                           Transaction in Own Shares
12/09/2006                           Director/PDMR Shareholding
11/09/2006                           Director/PDMR Shareholding
11/09/2006                           Settlement IRS Tax Dispute
08/09/2006                           Director/PDMR Shareholding
08/09/2006                           Director/PDMR Shareholding
07/09/2006                           Director/PDMR Shareholding
06/09/2006                           Director/PDMR Shareholding
05/09/2006                           Director/PDMR Shareholding
05/09/2006                           Director/PDMR Shareholding
04/09/2006                           Director/PDMR Shareholding
04/09/2006                           Director/PDMR Shareholding
04/09/2006                           Director/PDMR Shareholding
04/09/2006                           Director/PDMR Shareholding
01/09/2006                           Transaction in Own Shares
31/08/2006                           Director/PDMR Shareholding
30/08/2006                           Transaction in Own Shares
30/08/2006                           Director/PDMR Shareholding
30/08/2006                           Director/PDMR Shareholding
29/08/2006                           Director/PDMR Shareholding
29/08/2006                           Director/PDMR Shareholding
29/08/2006                           Director/PDMR Shareholding
24/08/2006                           Transaction in Own Shares
23/08/2006                           Transaction in Own Shares
23/08/2006                           Transaction in Own Shares
22/08/2006                           Transaction in Own Shares
22/08/2006                           Director/PDMR Shareholding
21/08/2006                           Director/PDMR Shareholding
21/08/2006                           Director/PDMR Shareholding
21/08/2006                           Director/PDMR Shareholding
18/08/2006                           Director/PDMR Shareholding
17/08/2006                           Transaction in Own Shares
16/08/2006                           Director/PDMR Shareholding
16/08/2006                           Transaction in Own Shares
16/08/2006                           Director/PDMR Shareholding
16/08/2006                           Director/PDMR Shareholding
14/08/2006                           Transaction in Own Shares
11/08/2006                           Director/PDMR Shareholding
11/08/2006                           Director/PDMR Shareholding
11/08/2006                           Director/PDMR Shareholding
10/08/2006                           Director/PDMR Shareholding
10/08/2006                           Director/PDMR Shareholding
10/08/2006                           Transaction in Own Shares
09/08/2006                           Director/PDMR Shareholding
09/08/2006                           Transaction in Own Shares
08/08/2006                           Transaction in Own Shares
07/08/2006                           Director/PDMR Shareholding
07/08/2006                           Director/PDMR Shareholding
07/08/2006                           Director/PDMR Shareholding
07/08/2006                           Transaction in Own Shares
04/08/2006                           Transaction in Own Shares
03/08/2006                           Transaction in Own Shares
02/08/2006                           Transaction in Own Shares
02/08/2006                           Director/PDMR Shareholding
01/08/2006                           Transaction in Own Shares
01/08/2006                           Director/PDMR Shareholding
01/08/2006                           Director/PDMR Shareholding
31/07/2006                           Director/PDMR Shareholding
31/07/2006                           Director/PDMR Shareholding
31/07/2006                           Director/PDMR Shareholding
28/07/2006                           Director/PDMR Shareholding
28/07/2006                           Director/PDMR Shareholding
27/07/2006                           Transaction in Own Shares
27/07/2006                           Director/PDMR Shareholding
27/07/2006                           Interim Report
26/07/2006                           Director/PDMR Shareholding
26/07/2006                           Director/PDMR Shareholding
26/07/2006                           Transaction in Own Shares
26/07/2006                           Interim Results
25/07/2006                           Transaction in Own Shares
25/07/2006                           Director/PDMR Shareholding
25/07/2006                           Director/PDMR Shareholding
24/07/2006                           Transaction in Own Shares
24/07/2006                           Director/PDMR Shareholding
24/07/2006                           Director/PDMR Shareholding
20/07/2006                           Transaction in Own Shares
20/07/2006                           Director/PDMR Shareholding
19/07/2006                           Director/PDMR Shareholding
19/07/2006                           Transaction in Own Shares
18/07/2006                           Director/PDMR Shareholding
18/07/2006                           Director/PDMR Shareholding
18/07/2006                           Director/PDMR Shareholding
18/07/2006                           Director/PDMR Shareholding
18/07/2006                           Transaction in Own Shares
17/07/2006                           Transaction in Own Shares
17/07/2006                           Director/PDMR Shareholding
17/07/2006                           Director/PDMR Shareholding
13/07/2006                           Director/PDMR Shareholding
13/07/2006                           Director Declaration
13/07/2006                           Transaction in Own Shares
13/07/2006                           Director/PDMR Shareholding
13/07/2006                           Director/PDMR Shareholding
12/07/2006                           Transaction in Own Shares
12/07/2006                           Director/PDMR Shareholding
12/07/2006                           Director/PDMR Shareholding
11/07/2006                           Transaction in Own Shares
11/07/2006                           Director/PDMR Shareholding
11/07/2006                           Director/PDMR Shareholding
11/07/2006                           Director/PDMR Shareholding
11/07/2006                           Director/PDMR Shareholding
11/07/2006                           Director/PDMR Shareholding
10/07/2006                           Director/PDMR Shareholding
10/07/2006                           Director/PDMR Shareholding
10/07/2006                           Transaction in Own Shares
10/07/2006                           Director/PDMR Shareholding
10/07/2006                           Director/PDMR Shareholding
10/07/2006                           Director/PDMR Shareholding
07/07/2006                           Transaction in Own Shares
07/07/2006                           Director/PDMR Shareholding
06/07/2006                           Director/PDMR Shareholding
06/07/2006                           Director/PDMR Shareholding
06/07/2006                           Director/PDMR Shareholding
05/07/2006                           Director/PDMR Shareholding
05/07/2006                           Transaction in Own Shares
05/07/2006                           Director/PDMR Shareholding
04/07/2006                           Director/PDMR Shareholding
04/07/2006                           Transaction in Own Shares
03/07/2006                           Director/PDMR Shareholding
03/07/2006                           Director/PDMR Shareholding
03/07/2006                           Director/PDMR Shareholding
30/06/2006                           Transaction in Own Shares
30/06/2006                           Publication of Reg. Document
29/06/2006                           Directorate Change
29/06/2006                           Directorate Change
28/06/2006                           Transaction in Own Shares
28/06/2006                           Director/PDMR Shareholding
27/06/2006                           Transaction in Own Shares
26/06/2006                           Director/PDMR Shareholding
26/06/2006                           Director/PDMR Shareholding
22/06/2006                           Transaction in Own Shares
22/06/2006                           Director/PDMR Shareholding
21/06/2006                           Transaction in Own Shares
20/06/2006                           Transaction in Own Shares
20/06/2006                           Director/PDMR Shareholding
20/06/2006                           Director/PDMR Shareholding
20/06/2006                           Director/PDMR Shareholding
20/06/2006                           Director/PDMR Shareholding
19/06/2006                           Director/PDMR Shareholding
19/06/2006                           Director/PDMR Shareholding
16/06/2006                           Director/PDMR Shareholding
15/06/2006                           Transaction in Own Shares
15/06/2006                           Director/PDMR Shareholding
15/06/2006                           Director/PDMR Shareholding
14/06/2006                           Transaction in Own Shares
14/06/2006                           Director/PDMR Shareholding
13/06/2006                           Director/PDMR Shareholding
13/06/2006                           Transaction in Own Shares
12/06/2006                           Director/PDMR Shareholding
12/06/2006                           Director/PDMR Shareholding
12/06/2006                           Director/PDMR Shareholding
12/06/2006                           Transaction in Own Shares
09/06/2006                           Director/PDMR Shareholding
09/06/2006                           Director/PDMR Shareholding
08/06/2006                           Transaction in Own Shares
07/06/2006                           Transaction in Own Shares
07/06/2006                           Director/PDMR Shareholding
07/06/2006                           Hedging transaction - Quest
06/06/2006                           Transaction in Own Shares
05/06/2006                           Director/PDMR Shareholding
05/06/2006                           Director/PDMR Shareholding
05/06/2006                           Director/PDMR Shareholding
05/06/2006                           Transaction in Own Shares
01/06/2006                           Transaction in Own Shares
31/05/2006                           Transaction in Own Shares
31/05/2006                           Director/PDMR Shareholding
31/05/2006                           Director/PDMR Shareholding
31/05/2006                           Additional Listing
30/05/2006                           Transaction in Own Shares
26/05/2006                           Director/PDMR Shareholding
25/05/2006                           Transaction in Own Shares
25/05/2006                           Director/PDMR Shareholding
24/05/2006                           Director/PDMR Shareholding
24/05/2006                           Director/PDMR Shareholding
24/05/2006                           Director/PDMR Shareholding
24/05/2006                           Director/PDMR Shareholding
24/05/2006                           Transaction in Own Shares
23/05/2006                           Transaction in Own Shares
23/05/2006                           Director/PDMR Shareholding
23/05/2006                           Director/PDMR Shareholding
22/05/2006                           Transaction in Own Shares
19/05/2006                           Holding(s) in Company
19/05/2006                           Director/PDMR Shareholding
18/05/2006                           Transaction in Own Shares
18/05/2006                           AGM Special Business
17/05/2006                           Result of AGM
17/05/2006                           Chairman's Statement
16/05/2006                           Director/PDMR Shareholding
16/05/2006                           Transaction in Own Shares
15/05/2006                           Transaction in Own Shares
15/05/2006                           Director/PDMR Shareholding
15/05/2006                           Director/PDMR Shareholding
15/05/2006                           Director/PDMR Shareholding
12/05/2006                           Director/PDMR Shareholding
11/05/2006                           Transaction in Own Shares
11/05/2006                           Director/PDMR Shareholding
11/05/2006                           Director/PDMR Shareholding
10/05/2006                           Transaction in Own Shares
10/05/2006                           Director/PDMR Shareholding
09/05/2006                           Director/PDMR Shareholding
09/05/2006                           Director/PDMR Shareholding
09/05/2006                           Director/PDMR Shareholding
09/05/2006                           Transaction in Own Shares
08/05/2006                           Director/PDMR Shareholding
08/05/2006                           Director/PDMR Shareholding
05/05/2006                           Director/PDMR Shareholding
04/05/2006                           Transaction in Own Shares
04/05/2006                           Director/PDMR Shareholding
03/05/2006                           Director/PDMR Shareholding
03/05/2006                           Transaction in Own Shares
03/05/2006                           Director/PDMR Shareholding
02/05/2006                           Director/PDMR Shareholding
02/05/2006                           Transaction in Own Shares
02/05/2006                           Director/PDMR Shareholding
28/04/2006                           Transaction in Own Shares
28/04/2006                           Director/PDMR Shareholding
28/04/2006                           Director/PDMR Shareholding
28/04/2006                           Director/PDMR Shareholding
27/04/2006                           1st Quarter Results
26/04/2006                           Director/PDMR Shareholding
25/04/2006                           Director/PDMR Shareholding
25/04/2006                           Director/PDMR Shareholding
25/04/2006                           Director/PDMR Shareholding
25/04/2006                           Director/PDMR Shareholding
25/04/2006                           Director/PDMR Shareholding
24/04/2006                           Director/PDMR Shareholding
24/04/2006                           Director/PDMR Shareholding
19/04/2006                           Director/PDMR Shareholding
19/04/2006                           Director/PDMR Shareholding
18/04/2006                           Director/PDMR Shareholding
18/04/2006                           Director/PDMR Shareholding
18/04/2006                           Director/PDMR Shareholding
18/04/2006                           Director/PDMR Shareholding
13/04/2006                           Director/PDMR Shareholding
13/04/2006                           Director/PDMR Shareholding
12/04/2006                           Director/PDMR Shareholding
12/04/2006                           Director/PDMR Shareholding
12/04/2006                           Director/PDMR Shareholding
12/04/2006                           Director/PDMR Shareholding
11/04/2006                           Director/PDMR Shareholding
11/04/2006                           Director/PDMR Shareholding
11/04/2006                           Director/PDMR Shareholding
11/04/2006                           Director/PDMR Shareholding
10/04/2006                           Director/PDMR Shareholding
10/04/2006                           Director/PDMR Shareholding
10/04/2006                           Director/PDMR Shareholding
10/04/2006                           Director/PDMR Shareholding
10/04/2006                           Director/PDMR Shareholding
10/04/2006                           Director/PDMR Shareholding
07/04/2006                           Director/PDMR Shareholding
04/04/2006                           Director/PDMR Shareholding
04/04/2006                           Director/PDMR Shareholding
04/04/2006                           Director/PDMR Shareholding
03/04/2006                           Director/PDMR Shareholding
03/04/2006                           Director/PDMR Shareholding
03/04/2006                           Tykerb Phase III Trial Update
31/03/2006                           Annual Information Update
31/03/2006                           Publication of Prospectus


2.                         Documents filed at Companies House

All documents listed below were filed with the Registrar of Companies in England and Wales on or around the dates 
indicated, and can be obtained from Companies House via their website www.companieshouse.gov.uk

Date         Document Type             Description of Document Filed

29/03/2007   288a              Appointment of Director
23/03/2007   169(1B)           Return by a public company purchasing its own shares for holding in treasury
23/03/2007   169(1B)           Return by a public company purchasing its own shares for holding in treasury
22/03/2007   88(2)R            Return of Allotment of Shares
22/03/2007   88(2)R            Return of Allotment of Shares
22/03/2007   88(2)R            Return of Allotment of Shares
22/03/2007   88(2)R            Return of Allotment of Shares
22/03/2007   88(2)R            Return of Allotment of Shares
22/03/2007   88(2)R            Return of Allotment of Shares
22/03/2007   88(2)R            Return of Allotment of Shares
22/03/2007   88(2)R            Return of Allotment of Shares
22/03/2007   88(2)R            Return of Allotment of Shares
22/03/2007   88(2)R            Return of Allotment of Shares
22/03/2007   88(2)R            Return of Allotment of Shares
22/03/2007   88(2)R            Return of Allotment of Shares
22/03/2007   88(2)R            Return of Allotment of Shares
22/03/2007   88(2)R            Return of Allotment of Shares
22/03/2007   88(2)R            Return of Allotment of Shares
22/03/2007   88(2)R            Return of Allotment of Shares
22/03/2007   88(2)R            Return of Allotment of Shares
22/03/2007   88(2)R            Return of Allotment of Shares
22/03/2007   88(2)R            Return of Allotment of Shares
22/03/2007   88(2)R            Return of Allotment of Shares
19/03/2007   169(1B)           Return by a public company purchasing its own shares for holding in treasury
19/03/2007   169(1B)           Return by a public company purchasing its own shares for holding in treasury
21/03/2007   88(2)R            Return of Allotment of Shares
15/03/2007   88(2)R            Return of Allotment of Shares
15/03/2007   88(2)R            Return of Allotment of Shares
15/03/2007   88(2)R            Return of Allotment of Shares
13/03/2007   88(2)R            Return of Allotment of Shares
06/03/2007   88(2)R            Return of Allotment of Shares
06/03/2007   88(2)R            Return of Allotment of Shares
06/03/2007   88(2)R            Return of Allotment of Shares
06/03/2007   88(2)R            Return of Allotment of Shares
06/03/2007   88(2)R            Return of Allotment of Shares
06/03/2007   88(2)R            Return of Allotment of Shares
06/03/2007   88(2)R            Return of Allotment of Shares
06/03/2007   88(2)R            Return of Allotment of Shares
06/03/2007   88(2)R            Return of Allotment of Shares
06/03/2007   88(2)R            Return of Allotment of Shares
02/03/2007   88(2)R            Return of Allotment of Shares
27/02/2007   88(2)R            Return of Allotment of Shares
27/02/2007   88(2)R            Return of Allotment of Shares
27/02/2007   88(2)R            Return of Allotment of Shares
27/02/2007   88(2)R            Return of Allotment of Shares
27/02/2007   88(2)R            Return of Allotment of Shares
27/02/2007   88(2)R            Return of Allotment of Shares
19/02/2007   88(2)R            Return of Allotment of Shares
19/02/2007   88(2)R            Return of Allotment of Shares
19/02/2007   88(2)R            Return of Allotment of Shares
19/02/2007   88(2)R            Return of Allotment of Shares
19/02/2007   88(2)R            Return of Allotment of Shares
19/02/2007   88(2)R            Return of Allotment of Shares
19/02/2007   88(2)R            Return of Allotment of Shares
19/02/2007   88(2)R            Return of Allotment of Shares
19/02/2007   88(2)R            Return of Allotment of Shares
19/02/2007   88(2)R            Return of Allotment of Shares
19/02/2007   88(2)R            Return of Allotment of Shares
19/02/2007   88(2)R            Return of Allotment of Shares
19/02/2007   88(2)R            Return of Allotment of Shares
19/02/2007   88(2)R            Return of Allotment of Shares
19/02/2007   88(2)R            Return of Allotment of Shares
19/02/2007   88(2)R            Return of Allotment of Shares
19/02/2007   88(2)R            Return of Allotment of Shares
19/02/2007   88(2)R            Return of Allotment of Shares
19/02/2007   88(2)R            Return of Allotment of Shares
15/02/2007   88(2)R            Return of Allotment of Shares
15/02/2007   88(2)R            Return of Allotment of Shares
15/02/2007   88(2)R            Return of Allotment of Shares
15/02/2007   88(2)R            Return of Allotment of Shares
08/02/2007   88(2)R            Return of Allotment of Shares
26/01/2007   88(2)R            Return of Allotment of Shares
26/01/2007   88(2)R            Return of Allotment of Shares
25/01/2007   88(2)R            Return of Allotment of Shares
23/01/2007   88(2)R            Return of Allotment of Shares
23/01/2007   88(2)R            Return of Allotment of Shares
23/01/2007   88(2)R            Return of Allotment of Shares
23/01/2007   88(2)R            Return of Allotment of Shares
23/01/2007   88(2)R            Return of Allotment of Shares
23/01/2007   88(2)R            Return of Allotment of Shares
23/01/2007   88(2)R            Return of Allotment of Shares
18/01/2007   88(2)R            Return of Allotment of Shares
18/01/2007   88(2)R            Return of Allotment of Shares
18/01/2007   88(2)R            Return of Allotment of Shares
12/01/2007   88(2)R            Return of Allotment of Shares
06/01/2007   88(2)R            Return of Allotment of Shares
06/01/2007   88(2)R            Return of Allotment of Shares
06/01/2007   88(2)R            Return of Allotment of Shares
06/01/2007   88(2)R            Return of Allotment of Shares
06/01/2007   88(2)R            Return of Allotment of Shares
06/01/2007   88(2)R            Return of Allotment of Shares
06/01/2007   88(2)R            Return of Allotment of Shares
06/01/2007   88(2)R            Return of Allotment of Shares
16/01/2007   363s              Annual Return
29/12/2006   88(2)R            Return of Allotment of Shares
18/12/2006   88(2)R            Return of Allotment of Shares
18/12/2006   88(2)R            Return of Allotment of Shares
18/12/2006   88(2)R            Return of Allotment of Shares
18/12/2006   88(2)R            Return of Allotment of Shares
18/12/2006   88(2)R            Return of Allotment of Shares
18/12/2006   88(2)R            Return of Allotment of Shares
18/12/2006   88(2)R            Return of Allotment of Shares
18/12/2006   88(2)R            Return of Allotment of Shares
18/12/2006   88(2)R            Return of Allotment of Shares
18/12/2006   88(2)R            Return of Allotment of Shares
18/12/2006   88(2)R            Return of Allotment of Shares
18/12/2006   88(2)R            Return of Allotment of Shares
11/12/2006   88(2)R            Return of Allotment of Shares
11/12/2006   88(2)R            Return of Allotment of Shares
11/12/2006   88(2)R            Return of Allotment of Shares
11/12/2006   88(2)R            Return of Allotment of Shares
11/12/2006   88(2)R            Return of Allotment of Shares
11/12/2006   88(2)R            Return of Allotment of Shares
11/12/2006   88(2)R            Return of Allotment of Shares
11/12/2006   88(2)R            Return of Allotment of Shares
11/12/2006   88(2)R            Return of Allotment of Shares
11/12/2006   88(2)R            Return of Allotment of Shares
11/12/2006   88(2)R            Return of Allotment of Shares
11/12/2006   88(2)R            Return of Allotment of Shares
11/12/2006   88(2)R            Return of Allotment of Shares
11/12/2006   88(2)R            Return of Allotment of Shares
11/12/2006   88(2)R            Return of Allotment of Shares
30/11/2006   169(1B)           Return by a public company purchasing its own shares for holding in treasury
24/11/2006   169(1B)           Return by a public company purchasing its own shares for holding in treasury
23/11/2006   88(2)R            Return of Allotment of Shares
17/11/2006   88(2)R            Return of Allotment of Shares
17/11/2006   88(2)R            Return of Allotment of Shares
17/11/2006   88(2)R            Return of Allotment of Shares
17/11/2006   88(2)R            Return of Allotment of Shares
17/11/2006   88(2)R            Return of Allotment of Shares
17/11/2006   88(2)R            Return of Allotment of Shares
17/11/2006   88(2)R            Return of Allotment of Shares
17/11/2006   88(2)R            Return of Allotment of Shares
17/11/2006   88(2)R            Return of Allotment of Shares
17/11/2006   88(2)R            Return of Allotment of Shares
17/11/2006   88(2)R            Return of Allotment of Shares
17/11/2006   88(2)R            Return of Allotment of Shares
17/11/2006   88(2)R            Return of Allotment of Shares
17/11/2006   88(2)R            Return of Allotment of Shares
17/11/2006   88(2)R            Return of Allotment of Shares
17/11/2006   88(2)R            Return of Allotment of Shares
17/11/2006   88(2)R            Return of Allotment of Shares
17/11/2006   88(2)R            Return of Allotment of Shares
15/11/2006   88(2)R            Return of Allotment of Shares
10/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
03/11/2006   88(2)R            Return of Allotment of Shares
31/10/2006   169(1B)           Return by a public company purchasing its own shares for holding in treasury
26/10/2006   88(2)R            Return of Allotment of Shares
19/10/2006   88(2)R            Return of Allotment of Shares
11/10/2006   88(2)R            Return of Allotment of Shares
11/10/2006   88(2)R            Return of Allotment of Shares
11/10/2006   169(1B)           Return by a public company purchasing its own shares for holding in treasury
26/09/2006   169(1B)           Return by a public company purchasing its own shares for holding in treasury
22/09/2006   88(2)R            Return of Allotment of Shares
22/09/2006   88(2)R            Return of Allotment of Shares
19/09/2006   169               Return by a company purchasing its own shares
13/09/2006   88(2)R            Return of Allotment of Shares
13/09/2006   88(2)R            Return of Allotment of Shares
13/09/2006   88(2)R            Return of Allotment of Shares
13/09/2006   88(2)R            Return of Allotment of Shares
13/09/2006   88(2)R            Return of Allotment of Shares
13/09/2006   88(2)R            Return of Allotment of Shares
13/09/2006   88(2)R            Return of Allotment of Shares
13/09/2006   88(2)R            Return of Allotment of Shares
13/09/2006   88(2)R            Return of Allotment of Shares
13/09/2006   88(2)R            Return of Allotment of Shares
13/09/2006   88(2)R            Return of Allotment of Shares
13/09/2006   88(2)R            Return of Allotment of Shares
13/09/2006   88(2)R            Return of Allotment of Shares
13/09/2006   88(2)R            Return of Allotment of Shares
13/09/2006   88(2)R            Return of Allotment of Shares
13/09/2006   88(2)R            Return of Allotment of Shares
13/09/2006   88(2)R            Return of Allotment of Shares
30/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   88(2)R            Return of Allotment of Shares
22/08/2006   169(1B)           Return of Allotment of Shares
18/08/2006   AA                Directors' Report and Accounts
17/08/2006   88(2)R            Return of Allotment of Shares
16/08/2006   169(1B)           Return by a public company purchasing its own shares for holding in treasury
04/08/2006   169(1B)           Return by a public company purchasing its own shares for holding in treasury
01/08/2006   AA                Directors' Report and Accounts
08/08/2006   288a              Appointment of Director
26/07/2006   169(1B)           Return by a public company purchasing its own shares for holding in treasury
21/07/2006   88(2)R            Return of Allotment of Shares
03/07/2006   88(2)R            Return of Allotment of Shares
29/06/2006   169(1B)           Return by a public company purchasing its own shares for holding in treasury
19/10/2006   88(2)R            Return of Allotment of Shares
27/06/2006   88(2)R            Return of Allotment of Shares
27/06/2006   88(2)R            Return of Allotment of Shares
27/06/2006   88(2)R            Return of Allotment of Shares
27/06/2006   88(2)R            Return of Allotment of Shares
27/06/2006   88(2)R            Return of Allotment of Shares
27/06/2006   88(2)R            Return of Allotment of Shares
27/06/2006   88(2)R            Return of Allotment of Shares
27/06/2006   88(2)R            Return of Allotment of Shares
27/06/2006   88(2)R            Return of Allotment of Shares
27/06/2006   88(2)R            Return of Allotment of Shares
27/06/2006   88(2)R            Return of Allotment of Shares
27/06/2006   88(2)R            Return of Allotment of Shares
27/06/2006   169(1B)           Return by a public company purchasing its own shares for holding in treasury
21/06/2006   88(2)R            Return of Allotment of Shares
19/06/2006   88(2)R            Return of Allotment of Shares
19/06/2006   88(2)R            Return of Allotment of Shares
19/06/2006   88(2)R            Return of Allotment of Shares
19/06/2006   88(2)R            Return of Allotment of Shares
19/06/2006   88(2)R            Return of Allotment of Shares
19/06/2006   88(2)R            Return of Allotment of Shares
19/06/2006   88(2)R            Return of Allotment of Shares
19/06/2006   88(2)R            Return of Allotment of Shares
19/06/2006   88(2)R            Return of Allotment of Shares
19/06/2006   88(2)R            Return of Allotment of Shares
08/06/2006   288b              Resignation of Director
06/06/2006   288a              Appointment of Director
26/05/2006   288b              Resignation of Director
25/05/2006   RES09             Dis-Applying Pre-Emption Rights
25/05/2006   88(2)R            Return of Allotment of Shares
25/05/2006   88(2)R            Return of Allotment of Shares
25/05/2006   88(2)R            Return of Allotment of Shares
25/05/2006   88(2)R            Return of Allotment of Shares
25/05/2006   88(2)R            Return of Allotment of Shares
25/05/2006   88(2)R            Return of Allotment of Shares
25/05/2006   88(2)R            Return of Allotment of Shares
25/05/2006   88(2)R            Return of Allotment of Shares
25/05/2006   88(2)R            Return of Allotment of Shares
25/05/2006   88(2)R            Return of Allotment of Shares
25/05/2006   88(2)R            Return of Allotment of Shares
25/05/2006   88(2)R            Return of Allotment of Shares
25/05/2006   88(2)R            Return of Allotment of Shares
25/05/2006   88(2)R            Return of Allotment of Shares
25/05/2006   88(2)R            Return of Allotment of Shares
25/05/2006   88(2)R            Return of Allotment of Shares
25/05/2006   88(2)R            Return of Allotment of Shares
25/05/2006   88(2)R            Return of Allotment of Shares
25/05/2006   88(2)R            Return of Allotment of Shares
30/05/2006   288a              Appointment of Director
23/05/2006   88(2)R            Return of Allotment of Shares
23/05/2006   88(2)R            Return of Allotment of Shares
23/05/2006   88(2)R            Return of Allotment of Shares
23/05/2006   88(2)R            Return of Allotment of Shares
23/05/2006   88(2)R            Return of Allotment of Shares
23/05/2006   88(2)R            Return of Allotment of Shares
23/05/2006   88(2)R            Return of Allotment of Shares
23/05/2006   88(2)R            Return of Allotment of Shares
18/05/2006   88(2)R            Return of Allotment of Shares
18/05/2006   88(2)R            Return of Allotment of Shares
18/05/2006   88(2)R            Return of Allotment of Shares
18/05/2006   88(2)R            Return of Allotment of Shares
18/05/2006   88(2)R            Return of Allotment of Shares
18/05/2006   88(2)R            Return of Allotment of Shares
18/05/2006   88(2)R            Return of Allotment of Shares
18/05/2006   88(2)R            Return of Allotment of Shares
18/05/2006   88(2)R            Return of Allotment of Shares
18/05/2006   88(2)R            Return of Allotment of Shares
18/05/2006   88(2)R            Return of Allotment of Shares
18/05/2006   88(2)R            Return of Allotment of Shares
18/05/2006   88(2)R            Return of Allotment of Shares
18/05/2006   88(2)R            Return of Allotment of Shares
18/05/2006   88(2)R            Return of Allotment of Shares
18/05/2006   88(2)R            Return of Allotment of Shares
18/05/2006   88(2)R            Return of Allotment of Shares
18/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   169(1B)           Return by a public company purchasing its own shares for holding in treasury
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
02/05/2006   88(2)R            Return of Allotment of Shares
28/04/2006   288c              Change of Particulars of Secretary
06/04/2006   169(1B)           Return by a public company purchasing its own shares for holding in treasury
04/04/2006   88(2)R            Return of Allotment of Shares
04/04/2006   88(2)R            Return of Allotment of Shares
04/04/2006   88(2)R            Return of Allotment of Shares
04/04/2006   88(2)R            Return of Allotment of Shares
03/04/2006   169(1B)           Return by a public company purchasing its own shares for holding in treasury
30/03/2006   169(1B)           Return by a public company purchasing its own shares for holding in treasury


3.                         Documents filed with the Securities and Exchange Commission ("SEC")

The Company submitted filings to the SEC in compliance with its obligations under national laws and rules dealing with 
the regulation of securities, issuers of securities and securities markets  by virtue of having American Depository 
Shares admitted to trading on the New York Stock Exchange. Full details of  these filings can be found on the SEC's 
website at www.sec.gov

4.                         Documents sent to shareholders

The following documents were published and sent to shareholders. They are available on the Company's website.

Date                                      Document

02/03/2007                            Annual Report and Accounts

02/03/2007                            Annual Review

22/03/2007                            Notice of Annual General Meeting


A copy of this Annual Information Update and copies of the documents referred to
in it can be obtained from the Deputy Company Secretary at the Company's
registered office:

Victoria Whyte
Deputy Company Secretary
GlaxoSmithKline plc
980 Great West Road
Brentford
Middlesex
TW8 9GS                              Tel: [phone]




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            The company news service from the London Stock Exchange