Buy-Back Programme

GlaxoSmithKline PLC
30 March 2007


GlaxoSmithKline plc (the "Company") announces that it has today put in place an
irrevocable, non-discretionary programme for the repurchase of its Ordinary
shares during the close period which precedes the 2007 first quarter results
announcement expected to be made on 25 April 2007.

The share buy-back programme will be managed by an independent third party which
makes its trading decisions in relation to the Company's securities
independently of, and uninfluenced by, the Company.

Any repurchases pursuant to these arrangements will be effected during the
period between 2 April 2007 and 25 April 2007 within certain pre-set parameters
and in accordance with both the Listing Rules and the limitations of the
repurchase authority granted to the Directors at the last Annual General Meeting
of shareholders.  Any Ordinary shares repurchased will be held as Treasury
shares.

S M Bicknell

Company Secretary


30 March 2007



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