Buy Back Programme

GlaxoSmithKline PLC
29 September 2006



                               Buy Back Programme



GlaxoSmithKline plc (the "Company") announces that it has today put in place an
irrevocable, non-discretionary programme for the repurchase of its ordinary
shares during the close period which precedes the third quarter results
announcement expected to be made on 26 October 2006.



The buy back programme will be managed by an independent third party which makes
its trading decisions in relation to the Company's securities independently of,
and uninfluenced by, the Company.



Any repurchases pursuant to these arrangements will be effected during the
period between 2 October 2006 and 26 October 2006 within certain pre-set
parameters and in accordance with both the Listing Rules and the limitations of
the repurchase authority granted to the Directors at the last Annual General
Meeting of shareholders.  Any ordinary shares repurchased will be held as
treasury shares.



S M Bicknell

Company Secretary





29 September 2006












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