Director/PDMR Shareholding

GlaxoSmithKline PLC
14 December 2005



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.

                                                       
  12 December 2005       Abacus (GSK) Trustees Limited, as trustee of the
                         GlaxoSmithKline Employee Trust, ("the GSK Trust"), 
                         transferred 14,400 Ordinary Shares in the Company to 
                         participants in the SmithKline Beecham Employee Share 
                         Option Plan 1991.

The Company was advised of these transactions on 13 December 2005.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J S Heslop are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R (1) (b).

S M Bicknell,
Company Secretary

14 December 2005


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