Director/PDMR Shareholding

GlaxoSmithKline PLC
26 August 2005


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.

               The Administrators of the GlaxoSmithKline US Retirement Savings 
               Plan ("the Plan") notified GlaxoSmithKline plc on 26 August 2005, 
               that as a result of a movement in the fund on 25 August 2005, the 
               number of Ordinary Share ADRs held by the fund had changed from 
               18,454,171 to 18,413,433 at an average price of $48.29.

The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).

S M Bicknell
Company Secretary

26 August 2005


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