Director/PDMR Shareholding

GlaxoSmithKline PLC
30 August 2006


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.

   29 August 2006          Abacus Corporate Trustees Limited, as trustee of the
                           GlaxoSmithKline (US) Trust, ("the GSK US Trust"), 
                           sold 6,480 Ordinary Share ADRs in the Company on 
                           behalf of participants in the GlaxoSmithKline Share 
                           Value Plan at a price of $55.68 per ADR.

                           The GSK US Trust transferred 13,739 Ordinary Share 
                           ADRs in the Company to participants in the 
                           GlaxoSmithKline Share Value Plan.

The Company was advised of these transactions on 29 August 2006.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr M M Slaoui
and Mr J S Heslop are therefore interested in the shares held in the GSK Trust
from time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).

S M Bicknell
Company Secretary

30 August 2006


                      This information is provided by RNS
            The company news service from the London Stock Exchange