Director/PDMR Shareholding

GlaxoSmithKline PLC
12 April 2006


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


The Administrators of the GlaxoSmithKline Performance Share Plan notified the
Company and the under-mentioned persons on 11 April 2006 of an increase in their
interests in Ordinary Share ADRs at a price of $51.88 per ADR following the
re-investment of the dividend paid to shareholders on 6 April 2006.

Dr F Calhoun                                           49.549
Dr J P Garnier                                         346.947
Mr D Phelan                                            74.344

This notification relates to a transaction notified in accordance with
Disclosure Rules 3.1.4R(1)(a) and 3.1.4R(1)(b).

S M Bicknell
Company Secretary

12 April 2006


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