Director/PDMR Shareholding

GlaxoSmithKline PLC
12 April 2006



         Notification of Transactions of Directors, Persons Discharging
                 Managerial Responsibility or Connected Persons


The Administrators of the GlaxoSmithKline Performance Share Plan notified the
Company and the under-mentioned persons on 11 April 2006 of an increase in their
notional interests in Ordinary Shares at a price of £14.66 per share and  ADRs
at a price of $51.14 per ADR following the notional re-investment of the
dividend paid to shareholders on 6 April 2006.

(Name of Director/PDMR)            (no of ADRs)

Mr R Bondy                         1,546.952 Ordinary shares          

Dr W Calhoun                       501.039 ADRs

Mr M Dunoyer                       582.618 Ordinary shares

Dr J P Garnier                     4,008.312 ADRs

Dr R Greig                         501.039 ADRs

Mr J Heslop                        152.735 Ordinary shares

Mr D Phelan                        771.600 ADRs

Dr D Pulman                        511.819 Ordinary shares
                                   245.792 ADRs

Mr D Stout                         1,483.075 ADRs

Mr C Viehbacher                    771.600 ADRs

Mr A Witty                         1,362.697 Ordinary shares

Dr T Yamada                        1,202.494 ADRs

Mrs J Younger                      351.580 Ordinary shares


The notional dividends accrued will be paid out in proportion to the percentage
of participants' Performance Share Plan holdings that vest following the end of
the relevant three year measurement period.

This notification relates to a transaction notified in accordance with
Disclosure Rules 3.1.4R(1)(a) and 3.1.4R(1)(b).

S M Bicknell
Company Secretary

12 April 2006






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