Director/PDMR Shareholding

GlaxoSmithKline PLC
05 September 2005





   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.


31 August 2005    The Administrators of the SmithKline Beecham Employee Benefit 
                  Trust ("the Trust") notified the Company on 5 September 2005 
                  that 4,037 Ordinary shares in the Company had been sold 
                  on 31 August 2005 on behalf of participants in the
                  GlaxoSmithKline Annual Investment Plan at a price of £13.36.

                  The Trust also notified the Company on 5 September 2005 that 
                  9,098 Ordinary shares had been transferred from the Trust to 
                  a participant in the GlaxoSmithKline Annual Investment Plan.


The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).



S M Bicknell
Company Secretary


5 September 2005



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