Director/PDMR Shareholding

GlaxoSmithKline PLC
05 September 2006



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.


   30 August 2006   The Administrators of the SmithKline Beecham Employee 
                    Benefit Trust ("the Trust") notified the Company on 
                    4 September 2006 that 12,272 Ordinary shares in the 
                    Company had been sold on 30 August 2006 on behalf of 
                    participants in the GlaxoSmithKline Bonus Investment 
                    Plan at a price of £14.82 per share.


The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J S Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.


This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).




S M Bicknell
Company Secretary


5 September 2006




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