Director/PDMR Shareholding

GlaxoSmithKline PLC
25 April 2006



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan ("The Plan"), which is notionally held in
GSK Ordinary Share ADRs, the Administrators of the Plan notified GlaxoSmithKline
plc and the under-mentioned person on 25 April 2006 of an increase in the
notional allocation of Ordinary Share ADRs on 21 April 2006 at a price of $53.01
per share:-


Dr R Greig                             1


This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(a).


S M Bicknell
Company Secretary
25 April 2006



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