Director/PDMR Shareholding

GlaxoSmithKline PLC
16 January 2007





   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.


         The Administrators of the GlaxoSmithKline US Retirement 
         Savings Plan ("the Plan") notified GlaxoSmithKline plc on 
         15 January 2007, that as a result of a movement in the 
         fund on 11 January 2007, the number of Ordinary Share 
         ADRs held by the fund had changed from 17,140,684 to 
         17,004,809 at an average price of $54.72

         The Administrators of the Plan notified GlaxoSmithKline plc 
         on 15 January 2007, that as a result of a movement in the
         fund on 12 January 2007, the number of Ordinary Share 
         ADRs held by the fund had changed from 17,004,809 to 
         17,028,609 at an average price of $53.07


The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J-P Garnier and Dr M M Slaoui are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).



S M Bicknell
Company Secretary

16 January 2007




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