Director/PDMR Shareholding

GlaxoSmithKline PLC
03 January 2006



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.


     The Administrators of the GlaxoSmithKline US Retirement Savings Plan ("the 
     Plan") notified GlaxoSmithKline plc on 3 January 2006, that as a result of 
     a movement in the fund on 29 December 2005, the number of Ordinary Share 
     ADRs held by the fund had changed from 18,452,425 to 18,437,908 at an 
     average price of $51.19

     The Administrators of the Plan notified GlaxoSmithKline plc on 3 January 
     2006, that as a result of a movement in the fund on 30 December 2005, the 
     number of Ordinary Share ADRs held by the fund had changed from 18,437,908 
     to 18,475,715 at an average price of $50.90


The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).


S M Bicknell
Company Secretary

3 January 2006


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