Director/PDMR Shareholding

GlaxoSmithKline PLC
11 January 2006

         Notification of Transactions of Directors, Persons Discharging
                 Managerial Responsibility or Connected Persons

The Administrators of the GlaxoSmithKline Performance Share Plan notified the
Company and the under-mentioned person on 10 January 2006 of an increase in
their notional interests in Ordinary Shares at a price of £14.61 per share and
Ordinary Share ADRs at a price of $51.96 per ADR following the notional
re-investment of the dividend paid to shareholders on 5 January 2006.

Mr R Bondy                                            1,101.210 Ordinary shares

Dr W Calhoun                                          356.879 ADRs

Mr M Dunoyer                                          414.741 Ordinary shares

Dr J P Garnier                                        2,855.029 ADRs

Dr R Greig                                            356.879 ADRs

Mr J Heslop                                           108.726 Ordinary shares

Mr D Phelan                                           549.593 ADRs

Dr D Pulman                                           364.343 Ordinary shares
                                                      175.072 ADRs

Mr D Stout                                            1,056.361 ADRs

Mr C Viehbacher                                       549.593 ADRs

Mr A Witty                                            970.047 Ordinary shares

Dr T Yamada                                           856.509 ADRs

Mrs J Younger                                         250.275 Ordinary shares

Mr J Ziegler                                          549.593 ADRs

The notional dividends accrued will be paid out in proportion to the percentage
of participants' Performance Share Plan holdings that vest following the end of
the relevant three year measurement period.

This notification relates to a transaction notified in accordance with
Disclosure Rules 3.1.4R(1)(a) and 3.1.4R(1)(b).

S M Bicknell
Company Secretary

11 January 2006


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