Director/PDMR Shareholding

GlaxoSmithKline PLC
27 January 2006

   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.


   24 January 2006               Abacus (GSK) Trustees Limited, as trustee of the
                                 GlaxoSmithKline Employee Trust, ("the GSK Trust"), sold 784
                                 Ordinary Shares in the Company on behalf of participants in the
                                 SmithKline Beecham Mid-Term Incentive Plan at a price of
                                 £14.34401 per share.


   24 January 2006               Abacus (GSK) Trustees Limited, as trustee of the GSK Trust,
                                 transferred 1,128 Ordinary Shares in the Company to
                                 participants in the SmithKline Beecham Mid-Term Incentive Plan.


   25 January 2006               Abacus (GSK) Trustees Limited, as trustee of the GSK Trust sold
                                 1,568 Ordinary Shares in the Company on behalf of participants
                                 in the SmithKline Beecham Mid-Term Incentive Plan at a price of
                                 £14.3728 per share.


   25 January 2006               Abacus (GSK) Trustees Limited, as trustee of the GSK Trust,
                                 transferred 2,256 Ordinary Shares in the Company to
                                 participants in the SmithKline Beecham Mid -Term Incentive
                                 Plan.


  25 January 2006                Abacus (GSK) Trustees Limited, as trustee of the GSK Trust,
                                 transferred 4,670 Ordinary Shares in the Company to
                                 participants in the SmithKline Beecham Employee Share Option
                                 Plan 1991.



The Company was advised of these transactions on 26 January 2006.



The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J S Heslop are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R (1) (b).



S M Bicknell

Company Secretary

27 January 2006




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