Director/PDMR Shareholding

GlaxoSmithKline PLC
31 January 2006




Notification of Transactions of Directors, Persons Discharging Managerial
Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.




The Administrators of the GlaxoSmithKline US Retirement Savings Plan ("the Plan") 
notified GlaxoSmithKline plc on 31 January 2006, that as a result of a movement in 
the fund on 27 January 2006, the number of Ordinary Share ADRs held by
the fund had changed from 18,075,774 to 18,046,998 at an average price of $51.11



The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R (1) (b).



S M Bicknell
Company Secretary



31 January 2006


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