Director/PDMR Shareholding

GlaxoSmithKline PLC
08 May 2006





   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.



       The Administrators of the GlaxoSmithKline US Retirement 
       Savings Plan ("the Plan") notified GlaxoSmithKline plc on 8 May 2006, 
       that as a result of a movement in the fund on 4 May 2006, the number of 
       Ordinary Share ADRs held by the fund had changed from 17,432,485 to 
       17,312,621 at a price of $55.45.



The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.


This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).


S M Bicknell
Company Secretary


8 May 2006






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