Director/PDMR Shareholding

GlaxoSmithKline PLC
27 September 2005




   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.




19 September 2005          The Administrators of the SmithKline Beecham Employee 
                           Benefit Trust ("the Trust") notified the Company on 
                           26 September 2005 that 1,249 Ordinary shares in the 
                           Company had been sold on 19 September 2005 on behalf 
                           of participants in the SmithKline Beecham Bonus 
                           Investment Plan at a price of £13.81.



                           The Trust also notified the Company on 26 September 
                           2005 that 1,809 Ordinary shares had been transferred 
                           from the Trust to participants in the SmithKline
                           Beecham Bonus Investment Plan.



                           The Trust also notified the Company on 26 September 
                           2005 that, in correction of an earlier administrative 
                           error, 4,419 Ordinary shares have been transferred 
                           from participants in the SmithKline Beecham Bonus 
                           Investment Plan to participants in the 
                           GlaxoSmithKline Annual Investment Plan.





The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).



S M Bicknell
Company Secretary


27 September 2005






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