Director/PDMR Shareholding

GlaxoSmithKline PLC
26 September 2006





   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.




18 September 2006          The Administrators of the SmithKline Beecham Employee Benefit Trust ("the
                           Trust") notified the Company on 25 September 2006 that 112 Ordinary shares in
                           the Company had been sold on 18 September 2006 on behalf of a participant in
                           the GlaxoSmithKline Annual Investment Plan at a price of £14.6233 per share.



                           The Trust also notified the Company on 25 September 2006 that 162 Ordinary
                           shares had been transferred on 18 September 2006 from the Trust to a
                           participant in the GlaxoSmithKline Annual Investment Plan.




18 September 2006



The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).





S M Bicknell

Company Secretary



26 September 2006






                      This information is provided by RNS
            The company news service from the London Stock Exchange