Director/PDMR Shareholding

GlaxoSmithKline PLC
15 May 2006





   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan ("The Plan"), which is notionally held in
GSK Ordinary Share ADRs, the Administrators of the Plan notified GlaxoSmithKline
plc and the under-mentioned persons on 15 May 2006 of an increase in the
notional allocation of Ordinary Share ADRs on 11 May 2006 at a price of $56.99
per share:-


Dr JP Garnier                                                          39
Dr T Yamada                                                            16
Dr F Calhoun                                                           9
Dr R Greig                                                             54
Mr D Phelan                                                            136
Dr D Pulman                                                            10
Mr D Stout                                                             23
Mr C Viehbacher                                                        3



This notification relates to a transaction notified in accordance with
Disclosure Rule

3.1.4R(1)(a).

S M Bicknell

Company Secretary

15 May 2006


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