Director/PDMR Shareholding

GlaxoSmithKline PLC
11 October 2006



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc in respect of the undermentioned persons arising
from the purchase of Ordinary Shares at a price of £14.64 per Ordinary Share on
10 October 2006 through the Company's ShareReward Plan ("the Plan") which the
under mentioned persons entered on 5 October 2001:

Mr J S Heslop            Acquisition of 8 Ordinary Shares under the 
                         partnership element of the Plan (personal contribution)

                         Acquisition of 8 Ordinary Shares under the 
                         matching element of the Plan (Company contribution)

Mr R Bondy               Acquisition of 8 Ordinary Shares under the partnership 
                         element of the Plan (personal contribution)

                         Acquisition of 8 Ordinary Shares under the matching 
                         element of the Plan (Company contribution)

Mr D Learmouth           Acquisition of 8 Ordinary Shares under the partnership 
                         element of the Plan (personal contribution)

                         Acquisition of 8 Ordinary Shares under the matching 
                         element of the Plan (Company contribution)

Mr A P Witty             Acquisition of 8 Ordinary Shares under the partnership 
                         element of the Plan (personal contribution)

                         Acquisition of 8 Ordinary Shares under the matching 
                         element of the Plan (Company contribution)

The Company and the above-mentioned persons were advised of this information on
11 October 2006.

This notification relates to a transaction notified in accordance with
Disclosure Rules 3.1.4R(1)(a) and 3.1.4R(1)(b).

S M Bicknell
Company Secretary

11 October 2006


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