Director/PDMR Shareholding

GlaxoSmithKline PLC
06 August 2007


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

I give below details of changes in interests in the Ordinary shares and American
Depositary Shares (ADSs) of GlaxoSmithKline plc in respect of the
under-mentioned Director and Persons Discharging Managerial Responsibility:-

Dr J-P Garnier                Exercise of options on 3 and 6 August 2007 over 
                              144,967 and 80,357 ADSs respectively, granted on 
                              13 November 1997, which would have lapsed on 12
                              November 2007, under the SmithKline Beecham 
                              Employee Share Option Plan 1991 at a price of 
                              $40.54 per ADS.

                              The sale of 144,967 ADSs on 3 August 2007 at an 
                              average price of $52.12 per ADS and 80,357 ADSs on 
                              6 August 2007 at an average price of $52.00 per 
                              ADS.

                              Following this transaction Dr Garnier's total 
                              shareholding in the Company is 505,824 ADSs, which 
                              includes 247,016 ADSs that have been earned but 
                              deferred under the share programmes operated by 
                              the Company. At the price at which the above ADSs 
                              were sold, Dr Garnier's holding is equivalent to 
                              more than 14 times his annual basic salary.

Mr D Stout                    Exercise of options on 3 August 2007 over 17,525 
                              ADSs granted on 30 October 1997, which would have 
                              lapsed on 29 October 2007, under the SmithKline
                              Beecham Employee Share Option Plan 1991 at a price 
                              of $40.54 per ADS.

                              The sale of 15,240 ADSs on 3 August 2007 at an 
                              average price of $51.80 per ADS.

The Company was advised of these transactions on 3 and 6 August 2007.

This notification is in accordance with Disclosure and Transparency Rules 3.1.4R
(1)(a) and 3.1.4R(1)(b).

S M Bicknell
Company Secretary

6 August 2007


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