Director/PDMR Shareholding

GlaxoSmithKline PLC
16 October 2006







   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.




28 September 2006          The Administrators of the SmithKline Beecham Employee Benefit Trust ("the
                           Trust") notified the Company on 16 October 2006 that 16,122 Ordinary shares in
                           the Company had been transferred on 28 September 2006 from the Trust to a
                           participant in the GlaxoSmithKline Annual Investment Plan.



                           The Trust also notified the Company on 16 October 2006 that 8,370 Ordinary
                           shares in the Company had been purchased on 11 October 2006 on behalf of a
                           participant in the GlaxoSmithKline Annual Investment Plan at a price of £14.59
                           per share.



11 October 2006            The Trust notified the Company on 16 October 2006 that 4,298 Ordinary shares
                           in the Company had been transferred on 11 October 2006 to a participant in the
                           GlaxoSmithKline Annual Investment Plan.



                           The Trust also notified the Company on 16 October 2006 that 532 Ordinary
                           shares in the Company had been purchased on 11 October 2006 on behalf of a
                           participant in the Bonus Investment Plan at a price of £14.59 per share.





The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J S Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).





S M Bicknell

Company Secretary



16 October 2006


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