Director/PDMR Shareholding

GlaxoSmithKline PLC
23 October 2006

   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan ("The Plan"), which is notionally held in
GSK Ordinary Share ADRs, the Administrators of the Plan notified GlaxoSmithKline
plc and the under-mentioned persons on 23 October 2006 of an increase in the
notional allocation of Ordinary Share ADRs on 20 October 2006 at a price of
$56.20 per share:-

Dr M M Slaoui            7
Dr R G Greig             1

This notification relates to a transaction notified in accordance with
Disclosure Rules 3.1.4R(1)(a) and 3.1.4R(1)(b).

S M Bicknell
Company Secretary

23 October 2006


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