Director/PDMR Shareholding

GlaxoSmithKline PLC
05 June 2006







   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.




   31 May 2006                   Abacus (GSK) Trustees Limited, as trustee of the
                                 GlaxoSmithKline Employee Trust, ("the GSK Trust"), transferred
                                 16,661 Ordinary Shares in the Company to participants in the
                                 SmithKline Beecham Employee Share Option Plan 1991.


    1 June 2006                  The GSK Trust transferred 4,200 Ordinary Shares in the Company
                                 to participants in the SmithKline Beecham Employee Share Option
                                 Plan 1991.





The Company was advised of these transactions on 2 June 2006.



The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Mr J S Heslop
and Dr M Slaoui are therefore interested in the shares held in the GSK Trust
from time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).







S M Bicknell

Company Secretary



5 June 2006


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