Director/PDMR Shareholding

GlaxoSmithKline PLC
12 June 2006






   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.


   8 June 2006    Abacus Corporate Trustee Limited, as trustee of the
                  GlaxoSmithKline (US) Trust, ("the GSK US Trust"), sold 426 ADR
                  Shares in the Company on behalf of  participants in the
                  GlaxoSmithKline Share Value Plan at a price of $55.23 per ADR
                  share.

                  The GSK US Trust transferred 885 ADR Shares to participants in
                  the  GlaxoSmithKline Share Value Plan.



The Company was advised of these transactions on 9 June 2006.



The GSK US Trust is a grantor trust of which all employees or former employees
of SmithKline Beecham Corporation and its subsidiaries are potential
beneficiaries. Two of the Company's directors, Dr J-P Garnier and Dr M M Slaoui
are therefore interested in the shares held in the GSK US Trust from time to
time in the same way as other employees or former employees of SmithKline
Beecham Corporation and its subsidiaries.



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).




S M Bicknell
Company Secretary



12 June 2006


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