Director/PDMR Shareholding

GlaxoSmithKline PLC
07 November 2006


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.



   30 October 2006         The Administrators of the SmithKline Beecham Employee Benefit Trust ("the
                           Trust") notified the Company on 6 November 2006 that 3,118 Ordinary shares in
                           the Company had been sold on 30 October 2006 on behalf of participants in the
                           SmithKline Beecham Bonus Investment Plan at a price of £13.99 per share.


                           The Trust also notified the Company on 6 November 2006 that 3,441 Ordinary
                           shares had been transferred from the Trust to a participant in the SmithKline
                           Beecham Bonus Investment Plan.



   30 October 2006         The Trust notified the Company on 6 November 2006 that 1,860 Ordinary shares
                           in the Company had been sold on 30 October 2006 on behalf of participants in
                           the SmithKline Beecham Annual Investment Plan at a price of £13.99 per share.


                           The Trust also notified the Company on 6 November 2006 that 2,053 Ordinary
                           shares had been transferred from the Trust to a participant in the SmithKline
                           Beecham Annual Investment Plan.




   31 October 2006         The Trust notified the Company on 6 November 2006 that 1,660 Ordinary shares
                           in the Company had been sold on 31 October 2006 on behalf of participants in
                           the SmithKline Beecham Annual Investment Plan at a price of £14.03 per share.


                           The Trust also notified the Company on 6 November 2006 that 5,544 Ordinary
                           shares had been transferred from the Trust to a participant in the SmithKline
                           Beecham Annual Investment Plan.



The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.


This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).


S M Bicknell
Company Secretary

7 November 2006

                      This information is provided by RNS
            The company news service from the London Stock Exchange