Director/PDMR Shareholding

GlaxoSmithKline PLC
13 February 2006


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.


   9 February 2006     Abacus (GSK) Trustees Limited, as trustee of the
                       GlaxoSmithKline Employee Trust, ("the GSK Trust"), 
                       transferred 153,971 Ordinary Shares in the Company to 
                       participants in the SmithKline Beecham Employee Share 
                       Option Plan 1991.


The Company was advised of these transactions on 10 February 2006.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J S Heslop are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.


This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).


S M Bicknell
Company Secretary

13 February 2006


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