Director/PDMR Shareholding

GlaxoSmithKline PLC
13 February 2006




   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.


   9 February 2006               Abacus (GSK) Trustees Limited, as trustee of the
                                 GlaxoSmithKline Employee Trust, ("the GSK Trust"), sold 4,444
                                 Ordinary Shares in the Company on behalf of participants in the
                                 SmithKline Beecham Mid-Term Incentive Plan at a price of £14.98
                                 per share.


                                 Abacus (GSK) Trustees Limited, as trustee of the GSK Trust,
                                 transferred 6,391 Ordinary Shares in the Company to
                                 participants in the SmithKline Beecham Mid-Term Incentive Plan.


The Company was advised of this transaction on 10 February 2006.



The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J S Heslop are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).







S M Bicknell

Company Secretary



13 February 2006


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