Director/PDMR Shareholding

GlaxoSmithKline PLC
10 November 2006

   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.

9 November 2006   Abacus (GSK) Trustees Limited, as trustee of the
                  GlaxoSmithKline Employee Trust, ("the GSK Trust"), transferred
                  3,000 Ordinary Shares in the Company to participants in the
                  SmithKline Beecham Employee Share Option Plan 1991.

The Company was advised of these transactions on 10 November 2006.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr M M Slaoui
and Mr J S Heslop are therefore interested in the shares held in the GSK Trust
from time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).

S M Bicknell
Company Secretary

10 November 2006


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