Director/PDMR Shareholding

GlaxoSmithKline PLC
12 October 2005


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc in respect of the under-mentioned persons arising
from the purchase of Ordinary Shares at a price of £14.48 per Ordinary Share on
11 October 2005 through the Company's ShareReward Plan ("the Plan") which the
under-mentioned persons entered on 5 October 2001:


Mr J S Heslop       Acquisition of 9 Ordinary Shares under the partnership 
                    element of the Plan (personal contribution)

                    Acquisition of 9 Ordinary Shares under the matching  
                    element of the Plan (Company contribution)

Mr R Bondy          Acquisition of 9 Ordinary Shares under the partnership  
                    element of the Plan (personal contribution)

                    Acquisition of 9 Ordinary Shares under the matching 
                    element of the Plan (Company contribution)

Mr A P Witty        Acquisition of 9 Ordinary Shares under the partnership  
                    element of the Plan (personal contribution)

                    Acquisition of 9 Ordinary Shares under the matching 
                    element of the Plan (Company contribution)

Mrs J V Younger     Acquisition of 9 Ordinary Shares under the partnership  
                    element of the Plan (personal contribution)

                    Acquisition of 9 Ordinary Shares under the matching 
                    element of the Plan (Company contribution)


The above-mentioned persons and the Company were advised of this information on
12 October 2005.

This notification relates to a transaction notified in accordance with
Disclosure Rules 3.1.4R(1)(a) and 3.1.4R(1)(b).


S M Bicknell
Company Secretary

12 October 2005



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