Director/PDMR Shareholding

GlaxoSmithKline PLC
13 October 2005



         Notification of Transactions of Directors, Persons Discharging
                 Managerial Responsibility or Connected Persons

The Administrators of the GlaxoSmithKline Performance Share Plan notified the
Company and the under-mentioned person on 13 October 2005 of an increase in
their notional interests in Ordinary Shares at a price of £13.35 per share and
Ordinary Share ADRs at a price of $48.00 per ADR following the notional
re-investment of the dividend paid to shareholders on 06 October 2005.

Mr R Bondy                                   1,196.184 Ordinary shares

Dr W Calhoun                                   375.531 ADR shares

Mr M Dunoyer                                   450.511 Ordinary shares

Dr J P Garnier                               3,004.241 ADR shares

Dr R Greig                                     375.531 ADR shares

Mr J Heslop                                    118.103 Ordinary shares

Mr D Phelan                                    578.316 ADR shares

Dr D Pulman                                    395.765 Ordinary shares
                                               184.222 ADR shares

Mr D Stout                                   1,111.569 ADR shares

Mr C Viehbacher                                578.316 ADR shares

Mr A Witty                                   1,053.708 Ordinary shares

Dr T Yamada                                    901.273 ADR shares

Mrs J Younger                                   271.86 Ordinary shares

Mr J Ziegler                                   578.316 ADR shares

The notional dividends accrued will be paid out in proportion to the percentage
of participants' Performance Share Plan holdings that vest following the end of
the relevant three year measurement period.

This notification relates to a transaction notified in accordance with
Disclosure Rules 3.1.4R(1)(a) and 3.1.4R(1)(b).

S M Bicknell
Company Secretary


13 October 2005


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