Director/PDMR Shareholding

GlaxoSmithKline PLC
20 February 2006



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.
                    
13 February 2006    The Administrators of the SmithKline Beecham Employee 
                    Benefit Trust ("the Trust") notified the Company on 
                    20 February 2006 that 820 Ordinary shares in the 
                    Company had been sold on 13 February 2006 on behalf of 
                    a participant in the SmithKline Beecham Bonus Investment 
                    Plan at a price of £14.96.

                    The Trust also notified the Company on 20 February that 
                    1,178 Ordinary shares had been transferred from the 
                    Trust to a participant in the SmithKline Beecham
                    Bonus Investment Plan.

15 February 2006    The Trust notified the Company on 20 February 2006 that 
                    1,820 Ordinary shares in the Company had been sold on 
                    15 February 2006 on behalf of a participant in the 
                    GlaxoSmithKline Annual Investment Plan at a price of 
                    £14.67.

                    The Trust also notified the Company on 20 February 2006 
                    that 2,562 Ordinary shares had been transferred from the 
                    Trust to a participant in the GlaxoSmithKline Annual 
                    Investment Plan.

The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).


S M Bicknell
Company Secretary

20 February 2006


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