Director/PDMR Shareholding

GlaxoSmithKline PLC
24 October 2005


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.
                         
 18 October 2005         The Administrators of the SmithKline Beecham Employee 
                         Benefit Trust ("the Trust") notified the Company on 
                         24 October 2005 that following reinvestment of the cash 
                         dividend paid to shareholders on 06 October 2005, 653 
                         Ordinary shares in the Company had been purchased on 
                         behalf of participants in the SmithKline Beecham Bonus 
                         Investment Plan at a price of £14.5364 per share.

 18 October 2005         The Trust also notified the Company on 24 October 2005 
                         that following reinvestment of the cash dividend paid 
                         to shareholders on 06 October 2005, 7,178 Ordinary 
                         Shares in the Company had been purchased for 
                         participants in the GlaxoSmithKline Annual Investment 
                         Plan at a price of £14.5364.

The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).


S M Bicknell
Company Secretary

24 October 2005


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